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Ground zero in Alzheimer's disease

New findings in preclinical Alzheimer's disease patients and mouse models of the disease suggest that it is the lateral, rather than the medial, entorhinal cortex that is most susceptible to tau pathology early in Alzheimer's disease. Aberrations begin here and spread to other cortical sites.

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Figure 1: Tau pathology progression in Alzheimer's disease.

Katie Vicari


  1. Witter, M.P. Hippocampus 3 (Spec. No), 33–44 (1993).

    PubMed  Google Scholar 

  2. Gómez-Isla, T. et al. J. Neurosci. 16, 4491–4500 (1996).

    Article  Google Scholar 

  3. Van Hoesen, G.W., Hyman, B.T. & Damasio, A.R. Hippocampus 1, 1–8 (1991).

    Article  CAS  Google Scholar 

  4. Braak, H. & Braak, E. Acta Neuropathol. 82, 239–259 (1991).

    Article  CAS  Google Scholar 

  5. Hargreaves, E.L., Rao, G., Lee, I. & Knierim, J.J. Science 308, 1792–1794 (2005).

    Article  CAS  Google Scholar 

  6. Hafting, T., Fyhn, M., Molden, S., Moser, M.-B. & Moser, E.I. Nature 436, 801–806 (2005).

    Article  CAS  Google Scholar 

  7. Khan, U. et al. Nat. Neurosci. 17, 304–311 (2014).

    Article  CAS  Google Scholar 

  8. Palop, J.J. & Mucke, L. Nat. Neurosci. 13, 812–818 (2010).

    Article  CAS  Google Scholar 

  9. Busche, M.A. et al. Science 321, 1686–1689 (2008).

    Article  CAS  Google Scholar 

  10. Sanchez, P.E. et al. Proc. Natl. Acad. Sci. USA 109, E2895–E2903 (2012).

    Article  CAS  Google Scholar 

  11. Bakker, A. et al. Neuron 74, 467–474 (2012).

    Article  CAS  Google Scholar 

  12. Insausti, R., Tuñón, T., Sobreviela, T., Insausti, A.M. & Gonzalo, L.M. J. Comp. Neurol. 355, 171–198 (1995).

    Article  CAS  Google Scholar 

  13. Suzuki, W.A. & Amaral, D.G. J. Comp. Neurol. 350, 497–533 (1994).

    Article  CAS  Google Scholar 

  14. Stranahan, A.M., Haberman, R.P. & Gallagher, M. Cereb. Cortex 21, 392–400 (2011).

    Article  Google Scholar 

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Correspondence to Michael A Yassa.

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Yassa, M. Ground zero in Alzheimer's disease. Nat Neurosci 17, 146–147 (2014).

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