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Ground zero in Alzheimer's disease

New findings in preclinical Alzheimer's disease patients and mouse models of the disease suggest that it is the lateral, rather than the medial, entorhinal cortex that is most susceptible to tau pathology early in Alzheimer's disease. Aberrations begin here and spread to other cortical sites.

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Figure 1: Tau pathology progression in Alzheimer's disease.

Katie Vicari

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Correspondence to Michael A Yassa.

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Yassa, M. Ground zero in Alzheimer's disease. Nat Neurosci 17, 146–147 (2014). https://doi.org/10.1038/nn.3631

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