A study reveals that SIRPα is released from postsynaptic neurons to induce and mature their synaptic inputs, using CD47 as the presynaptic receptor. SIRPα is cleaved in an activity-dependent manner to act as retrograde signal.
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Marina Corral Spence
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Biederer, T. Synaptic uSIRPation: the active neuron reigns over presynaptic partners. Nat Neurosci 16, 1361–1362 (2013). https://doi.org/10.1038/nn.3523
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DOI: https://doi.org/10.1038/nn.3523
