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Spermidine cures flies of senior moments

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Gupta et al. report in this issue that, in Drosophila melanogaster, a dietary supplement of spermidine—a polyamine originally isolated from semen—protects against cognitive aging by acting through the autophagic pathway.

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Figure 1: Possible mechanisms for protection against cognitive aging by dietary spermidine.

References

  1. Bishop, N.A., Lu, T. & Yanker, B.A. Nature 464, 529–535 (2010).

    Article  CAS  Google Scholar 

  2. Eisenberg, T. et al. Nat. Cell Biol. 11, 1305–1314 (2009).

    Article  CAS  Google Scholar 

  3. Simonsen, A. et al. Autophagy 4, 176–184 (2009).

    Article  Google Scholar 

  4. Gupta, V.K. et al. Nat. Neurosci. 16, 1451–1458 (2013).

    Article  Google Scholar 

  5. Minois, N. et al. Cell Death Dis. 3, e401 (2012).

    Article  CAS  Google Scholar 

  6. Ramot, Y. et al. PLoS ONE 6, e22564 (2011).

    Article  CAS  Google Scholar 

  7. Davis, R.L. Annu. Rev. Neurosci. 28, 275–302 (2005).

    Article  CAS  Google Scholar 

  8. Tomchik, S.M. & Davis, R.L. in Invertebrate Learning and Memory (eds. Menzel, R. & Benjamin, P.) 357–377 (Academic Press, San Diego, California, 2013).

    Google Scholar 

  9. Partridge, L. et al. Exp. Gerontol. 46, 376–381 (2011).

    Article  CAS  Google Scholar 

  10. Das, R. & Kanungo, M.S. Exp. Gerontol. 17, 95–103 (1982).

    Article  CAS  Google Scholar 

  11. Vivó, M. et al. Neurosci. Lett. 304, 107–111 (2001).

    Article  Google Scholar 

  12. Rubinsztein, D.C., Guillermo, M. & Kroemer, G. Cell 146, 682–695 (2011).

    Article  CAS  Google Scholar 

  13. Gräff, J. & Tsai, L. Annu. Rev. Pharmacol. Toxicol. 53, 311–330 (2013).

    Article  Google Scholar 

  14. Igarashi, K. & Kashiwagi, K. Int. J. Biochem. Cell Biol. 42, 39–51 (2010).

    Article  CAS  Google Scholar 

  15. Li, J., Doyle, K.M. & Tatlisumak, T. Curr. Med. Chem. 14, 807–813 (2007).

    Google Scholar 

Download references

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Correspondence to Ronald L Davis.

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The author declares no competing financial interests.

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Davis, R. Spermidine cures flies of senior moments. Nat Neurosci 16, 1363–1364 (2013). https://doi.org/10.1038/nn.3518

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