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The Top3β way to untangle RNA

Nature Neuroscience volume 16, pages 1163–1164 (2013)Cite this article

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With evidence from model organisms and human population genetic analysis, two studies in this issue report discoveries that eukaryotic Top3β has RNA topoisomerase activity and, in a ribonucleoprotein complex with FMRP, is important for neurodevelopment and normal cognition.

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Figure 1: Top3β is an RNA topoisomerase that, together with FMRP, is important for neurodevelopment.

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Authors and Affiliations

  1. Department of Brain and Cognitive Sciences, Alexi Nott and Li-Huei Tsai are at the Picower Institute for Learning and Memory, Massachusetts Institute for Technology, Cambridge, Massachusetts, USA.,

    Alexi Nott & Li-Huei Tsai

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  1. Alexi Nott
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  2. Li-Huei Tsai
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Correspondence to Li-Huei Tsai.

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The authors declare no competing financial interests.

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Nott, A., Tsai, LH. The Top3β way to untangle RNA. Nat Neurosci 16, 1163–1164 (2013). https://doi.org/10.1038/nn.3506

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