Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TMEM16C cuts pain no SLACK

Nature Neuroscience volume 16, pages 1165–1166 (2013)Cite this article

Subjects

TMEM16C has an unexpected role in regulating the activity and cell surface expression of sodium-activated potassium (SLACK) channels. By enhancing SLACK currents, TMEM16C indirectly inhibits pain signaling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regulation of SLACK channels by TMEM16C.

Katie Vicari

References

  1. Cho, H. et al. Nat. Neurosci. 15, 1015–1021 (2012).

    Article  CAS  Google Scholar 

  2. Tian, Y., Schreiber, R. & Kunzelmann, K. J. Cell Sci. 125, 4991–4998 (2012).

    Article  CAS  Google Scholar 

  3. Duran, C., Qu, Z., Osunkoya, A.O., Cui, Y. & Hartzell, H.C. Am. J. Physiol. Cell Physiol. 302, C482–C493 (2012).

    Article  CAS  Google Scholar 

  4. Milenkovic, V.M., Brockmann, M., Stöhr, H., Weber, B.H. & Strauss, O. BMC Evol. Biol. 10, 319 (2010).

    Article  Google Scholar 

  5. Huang, F. et al. Nat. Neurosci. 16, 1284–1290 (2013).

    Article  CAS  Google Scholar 

  6. Nuwer, M.O., Picchione, K.E. & Bhattacharjee, A. J. Neurosci. 30, 14165–14172 (2010).

    Article  CAS  Google Scholar 

  7. Santi, C.M. et al. J. Neurosci. 26, 5059–5068 (2006).

    Article  CAS  Google Scholar 

  8. Charlesworth, G. et al. Am. J. Hum. Genet. 91, 1041–1050 (2012).

    Article  CAS  Google Scholar 

  9. Heron, S.E. et al. Nat. Genet. 44, 1188–1190 (2012).

    Article  CAS  Google Scholar 

  10. Yang, Y.D. et al. Nature 455, 1210–1215 (2008).

    Article  CAS  Google Scholar 

  11. Caputo, A. et al. Science 322, 590–594 (2008).

    Article  CAS  Google Scholar 

  12. Yang, H. et al. Cell 151, 111–122 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Vinicius M. Gadotti and Gerald W. Zamponi are in the Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.,

    Vinicius M Gadotti & Gerald W Zamponi

Authors
  1. Vinicius M Gadotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gerald W Zamponi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gerald W Zamponi.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gadotti, V., Zamponi, G. TMEM16C cuts pain no SLACK. Nat Neurosci 16, 1165–1166 (2013). https://doi.org/10.1038/nn.3497

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3497

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing