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Bidirectional effects of aversive learning on perceptual acuity are mediated by the sensory cortex

Abstract

Although emotional learning affects sensory acuity, little is known about how these changes are facilitated in the brain. We found that auditory fear conditioning in mice elicited either an increase or a decrease in frequency discrimination acuity depending on how specific the learned response was to the conditioned tone. Using reversible pharmacological inactivation, we found that the auditory cortex mediated learning-evoked changes in acuity in both directions.

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Figure 1: AFC resulting in low and high learning specificity led to an increase and a decrease in frequency discrimination threshold (θ), respectively.
Figure 2: Learning specificity following fine AFC was negatively correlated with the frequency discrimination threshold.
Figure 3: Inactivation of the auditory cortex reversibly canceled the effect of AFC on θ, but did not affect learning specificity.

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Acknowledgements

We thank L. Mwilambwe-Tshilobo, D. Mohabir, A. Nguyen and L. Liu for technical assistance. M.N.G. is the recipient of the Burroughs Wellcome Fund Career Award at the Scientific Interface. The work was supported by the Klingenstein Award in Neuroscience, the Pennsylvania Lions Club Hearing Fellowship and the Penn Medicine Neuroscience Center Pilot grant to M.N.G.

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M.A. and M.N.G. designed the experiments, analyzed the data, prepared the figures and wrote the manuscript. M.A. carried out the experiments.

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Correspondence to Maria Neimark Geffen.

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The authors declare no competing financial interests.

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Aizenberg, M., Geffen, M. Bidirectional effects of aversive learning on perceptual acuity are mediated by the sensory cortex. Nat Neurosci 16, 994–996 (2013). https://doi.org/10.1038/nn.3443

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