The effects of neural gain on attention and learning

Abstract

Attention is commonly thought to be manifest through local variations in neural gain. However, what would be the effects of brain-wide changes in gain? We hypothesized that global fluctuations in gain modulate the breadth of attention and the degree to which processing is focused on aspects of the environment to which one is predisposed to attend. We found that measures of pupil diameter, which are thought to track levels of locus coeruleus norepinephrine activity and neural gain, were correlated with the degree to which learning was focused on stimulus dimensions that individual human participants were more predisposed to process. In support of our interpretation of this effect in terms of global changes in gain, we found that the measured pupillary and behavioral variables were strongly correlated with global changes in the strength and clustering of functional connectivity, as brain-wide fluctuations of gain would predict.

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Figure 1: The effect of gain on attention and learning.
Figure 2: Relationship between learning performance and ILS scores.
Figure 3: Relationship between pupil diameter and BOLD response to task-relevant and task-irrelevant stimuli.
Figure 4: Simulation of the effect of global changes in gain on functional connectivity strength and clustering.
Figure 5: Global fluctuations in local functional connectivity.
Figure 6: Pupil diameter and whole-brain functional connectivity.
Figure 7: Pupil diameter and local functional connectivity.
Figure 8: The clustering of functional connections, pupil diameter and task performance.

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Acknowledgements

We thank N. Turk-Browne and P. Dayan for helpful comments on earlier versions of the manuscript. This research was funded by US National Institutes of Health grants R03 DA029073 and R01 MH098861, a Howard Hughes Medical Institute International Student Research fellowship to E.E. and a Sloan Research Fellowship to Y.N. The authors also wish to thank the generous support of the Regina and John Scully Center for the Neuroscience of Mind and Behavior in the Princeton Neuroscience Institute.

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E.E. and Y.N. designed the study with consultation from J.D.C. E.E. and Y.N. analyzed the data, and all of the authors contributed to discussion and interpretation of the findings and writing the manuscript.

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Correspondence to Eran Eldar.

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The authors declare no competing financial interests.

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Supplementary Figures 1–7 and Supplementary Table 1 (PDF 2798 kb)

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Eldar, E., Cohen, J. & Niv, Y. The effects of neural gain on attention and learning. Nat Neurosci 16, 1146–1153 (2013). https://doi.org/10.1038/nn.3428

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