Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The uncertainty of it all

Two studies in this issue report the discovery of different types of uncertainty signals in little-studied, but critical, regions of the forebrain: decision confidence in the pulvinar and reward risk in the anterodorsal septum.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Reward risk–type uncertainty is represented in the ADS.
Figure 2: Decision confidence is represented in the pulvinar.

References

  1. Dayan, P., Kakade, S. & Montague, P.R. Nat. Neurosci. 3, 1218–1223 (2000).

    CAS  Article  Google Scholar 

  2. Monosov, I.E. & Hikosaka, O. Nat. Neurosci. 16, 749–755 (2013).

    Article  Google Scholar 

  3. Komura, Y., Nikkuni, A., Hirashima, N., Uetake, T. & Miyamoto, A. Nat. Neurosci. 16, 756–762 (2013).

    Article  Google Scholar 

  4. Huettel, S.A., Stowe, C.J., Gordon, E.M., Warner, B.T. & Platt, M.L. Neuron 49, 765–775 (2006).

    CAS  Article  Google Scholar 

  5. Sugrue, L.P., Corrado, G.S. & Newsome, W.T. Science 304, 1782–1787 (2004).

    CAS  Article  Google Scholar 

  6. De Martino, B., Fleming, S.M., Garrett, N. & Dolan, R.J. Nat. Neurosci. 16, 105–110 (2013).

    CAS  Article  Google Scholar 

  7. Maunsell, J.H. Trends Cogn. Sci. 8, 261–265 (2004).

    Article  Google Scholar 

  8. Fiorillo, C.D., Tobler, P.N. & Schultz, W. Science 299, 1898–1902 (2003).

    CAS  Article  Google Scholar 

  9. McCoy, A.N. & Platt, M.L. Nat. Neurosci. 8, 1220–1227 (2005).

    CAS  Article  Google Scholar 

  10. O'Neill, M. & Schultz, W. Neuron 68, 789–800 (2010).

    CAS  Article  Google Scholar 

  11. Kepecs, A., Uchida, N., Zariwala, H.A. & Mainen, Z.F. Nature 455, 227–231 (2008).

    CAS  Article  Google Scholar 

  12. Kiani, R., & Shadlen, M.N. Science 324, 759–764 (2009).

    CAS  Article  Google Scholar 

  13. Middlebrooks, P.G. & Sommer, M.A. Neuron 75, 517–530 (2012).

    CAS  Article  Google Scholar 

  14. Rahnev, D.A., Maniscalco, B., Luber, B., Lau, H. & Lisanby, S.H. J. Neurophysiol. 107, 1556–1563 (2012).

    Article  Google Scholar 

  15. Desimone, R., Wessinger, M., Thomas, L. & Schneider, W. Cold Spring Harb. Symp. Quant. Biol. 55, 963–971 (1990).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Adam Kepecs.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kepecs, A. The uncertainty of it all. Nat Neurosci 16, 660–662 (2013). https://doi.org/10.1038/nn.3416

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3416

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing