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Ganglionic eminence graft pre-eminence in epilepsy

Nature Neuroscience volume 16, pages 656658 (2013) | Download Citation

Intrahippocampal transplantation of inhibitory interneuron progenitors derived from the medial ganglionic eminence markedly ameliorates the seizure activity and neurobehavioral deficits typically observed in the pilocarpine mouse model of mesial temporal lobe epilepsy, even if the cells are engrafted after the onset of spontaneous seizures.

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Author information

Affiliations

  1. Jack M. Parent is in the Department of Neurology and Neuroscience Graduate Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

    • Jack M Parent
  2. Geoffrey G. Murphy is in the Department of Molecular and Integrative Physiology, Molecular and Behavioral Neuroscience Institute, and Neuroscience Graduate Program, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

    • Geoffrey G Murphy

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Jack M Parent or Geoffrey G Murphy.

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DOI

https://doi.org/10.1038/nn.3406

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