Intrahippocampal transplantation of inhibitory interneuron progenitors derived from the medial ganglionic eminence markedly ameliorates the seizure activity and neurobehavioral deficits typically observed in the pilocarpine mouse model of mesial temporal lobe epilepsy, even if the cells are engrafted after the onset of spontaneous seizures.
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Parent, J., Murphy, G. Ganglionic eminence graft pre-eminence in epilepsy. Nat Neurosci 16, 656–658 (2013). https://doi.org/10.1038/nn.3406
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DOI: https://doi.org/10.1038/nn.3406
