We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
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Belancio, V.P., Hedges, D.J. & Deininger, P. Genome Res. 18, 343–358 (2008).
Goodier, J.L. & Kazazian, H.H. Jr. Cell 135, 23–35 (2008).
Muotri, A.R. et al. Nature 435, 903–910 (2005).
Coufal, N.G. et al. Nature 460, 1127–1131 (2009).
Baillie, J.K. et al. Nature 479, 534–537 (2011).
Lathe, R. & Harris, A. J. Mol. Biol. 392, 813–822 (2009).
Muotri, A.R. et al. Nature 468, 443–446 (2010).
Jeong, B.H., Lee, Y.J., Carp, R.I. & Kim, Y.S. J. Clin. Virol. 47, 136–142 (2010).
Coufal, N.G. et al. Proc. Natl. Acad. Sci. USA 108, 20382–20387 (2011).
Douville, R., Liu, J., Rothstein, J. & Nath, A. Ann. Neurol. 69, 141–151 (2011).
Kaneko, H. et al. Nature 471, 325–330 (2011).
Tan, H. et al. Hum. Mol. Genet. 21, 57–65 (2012).
Li, W., Jin, Y., Prazak, L., Hammell, M. & Dubnau, J. PLoS ONE 7, e44099 (2012).
Czech, B. & Hannon, G.J. Nat. Rev. Genet. 12, 19–31 (2011).
Labrador, M., Sha, K., Li, A. & Corces, V.G. Genetics 180, 1367–1378 (2008).
Schwaerzel, M., Heisenberg, M. & Zars, T. Neuron 35, 951–960 (2002).
Dubnau, J. & Chiang, A.S. Curr. Opin. Neurobiol. 23, 84–91 (2013).
Lim, D.H. et al. FEBS Lett. 585, 3079–3085 (2011).
Liu, N. et al. Nature 482, 519–523 (2012).
Chen, Y., Pane, A. & Schupbach, T. Curr. Biol. 17, 637–642 (2007).
Tully, T., Preat, T., Boynton, S.C. & Del Vecchio, M. Cell 79, 35–47 (1994).
Qin, H. et al. Curr. Biol. 22, 608–614 (2012).
Chen, G. et al. PLoS Comput. Biol. 4, e1000026 (2008).
Song, S.U., Gerasimova, T., Kurkulos, M., Boeke, J.D. & Corces, V.G. Genes Dev. 8, 2046–2057 (1994).
We thank B. Czech and G. Hannon (Cold Spring Harbor Laboratory) for the Ago2414 and loki RNAi fly lines, F.-B. Gao (University of Massachusetts Medical School) for the Ago251B fly line, B. Dickson (Institute of Molecular Pathology) for the UAS∷Ago2 transgenic fly line, M. Welte (University of Rochester) for the Ago2454 fly line, T. Lee (Janelia Farm Research Campus) for the pTub-GAL80 in Casper4 plasmid, J. Boek (Johns Hopkins University School of Medicine) for the 7B3 hybridoma cell line, and C. Bautista at the Cold Spring Harbor Laboratory shared resources for ascites production. We thank T. Russel for technical assistance in construction of the gypsy reporter system. We also are grateful to S. Waddell, J. Beshel, M. Cressy, B. Czech, G. Hannon, K. Honegger, J. Huang, M. Kernan, R. Martienssen, H. Qin, C. Sandoval, Y. Shuai, G. Turner, T. Zador and Y. Zhong for helpful discussions or comments on the manuscript. This work was supported by US National Institutes of Health grant TR01(5R01NS067690-03) and DART NeuroScience LLC awarded to J.D. S.G. received additional support from the Shakespeare Fellowship and the Ernst Göhner Foundation.
This work was funded in part by DART NeuroScience LLC via a research grant to J.D.
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Li, W., Prazak, L., Chatterjee, N. et al. Activation of transposable elements during aging and neuronal decline in Drosophila. Nat Neurosci 16, 529–531 (2013). https://doi.org/10.1038/nn.3368
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