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Dangerous duet: LRRK2 and α-synuclein jam at CMA

A report suggests that leucine-rich repeat kinase 2 (LRRK2) can be degraded through chaperone-mediated autophagy (CMA) in the lysosome, and several Parkinson's disease–causing LRRK2 mutants impair CMA-mediated selective degradation of cytosolic substrates.

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Figure 1: The interaction between LRRK2 and α-synuclein in chaperone-mediated autophagy in Parkinson's disease cells.


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Correspondence to Zhenyu Yue or X William Yang.

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Yue, Z., Yang, X. Dangerous duet: LRRK2 and α-synuclein jam at CMA. Nat Neurosci 16, 375–377 (2013).

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