Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Dangerous duet: LRRK2 and α-synuclein jam at CMA

A report suggests that leucine-rich repeat kinase 2 (LRRK2) can be degraded through chaperone-mediated autophagy (CMA) in the lysosome, and several Parkinson's disease–causing LRRK2 mutants impair CMA-mediated selective degradation of cytosolic substrates.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The interaction between LRRK2 and α-synuclein in chaperone-mediated autophagy in Parkinson's disease cells.

References

  1. 1

    Orenstein, S.J. et al. Nat. Neurosci. 16, 394–406 (2013).

    CAS  Article  Google Scholar 

  2. 2

    Kaushik, S. & Cuervo, A.M. Trends Cell Biol. 22, 407–417 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Martin, I. et al. Annu. Rev. Genomics Hum. Genet. 12, 301–325 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Ko, H.S. et al. Proc. Natl. Acad. Sci. USA 106, 2897–2902 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Lichtenberg, M. et al. Cell Death Dis. 2, e196 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Plowey, E.D. et al. J. Neurochem. 105, 1048–1056 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Tong, Y. et al. Proc. Natl. Acad. Sci. USA 107, 9879–9884 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Yue, Z. & Lachenmayer, M.L. Mov. Disord. 26, 1386–1397 (2011).

    Article  Google Scholar 

  9. 9

    Cuervo, A.M. et al. Science 305, 1292–1295 (2004).

    CAS  Article  Google Scholar 

  10. 10

    Martinez-Vicente, M. et al. J. Clin. Invest. 118, 777–788 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. 11

    Lin, X. et al. Neuron 64, 807–827 (2009).

    CAS  Article  Google Scholar 

  12. 12

    Daher, J.P. et al. Hum. Mol. Genet. 21, 2420–2431 (2012).

    CAS  Article  Google Scholar 

  13. 13

    Herzig, M.C. et al. PLoS ONE 7, e36581 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Mazzulli, J.R. et al. Cell 146, 37–52 (2011).

    CAS  Article  Google Scholar 

  15. 15

    Usenovic, M. et al. J. Neurosci. 32, 4240–4246 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Zhenyu Yue or X William Yang.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Yue, Z., Yang, X. Dangerous duet: LRRK2 and α-synuclein jam at CMA. Nat Neurosci 16, 375–377 (2013). https://doi.org/10.1038/nn.3361

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing