A report suggests that leucine-rich repeat kinase 2 (LRRK2) can be degraded through chaperone-mediated autophagy (CMA) in the lysosome, and several Parkinson's disease–causing LRRK2 mutants impair CMA-mediated selective degradation of cytosolic substrates.
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Dysregulation of autophagy and mitochondrial function in Parkinson’s disease
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References
Orenstein, S.J. et al. Nat. Neurosci. 16, 394–406 (2013).
Kaushik, S. & Cuervo, A.M. Trends Cell Biol. 22, 407–417 (2012).
Martin, I. et al. Annu. Rev. Genomics Hum. Genet. 12, 301–325 (2011).
Ko, H.S. et al. Proc. Natl. Acad. Sci. USA 106, 2897–2902 (2009).
Lichtenberg, M. et al. Cell Death Dis. 2, e196 (2011).
Plowey, E.D. et al. J. Neurochem. 105, 1048–1056 (2008).
Tong, Y. et al. Proc. Natl. Acad. Sci. USA 107, 9879–9884 (2010).
Yue, Z. & Lachenmayer, M.L. Mov. Disord. 26, 1386–1397 (2011).
Cuervo, A.M. et al. Science 305, 1292–1295 (2004).
Martinez-Vicente, M. et al. J. Clin. Invest. 118, 777–788 (2008).
Lin, X. et al. Neuron 64, 807–827 (2009).
Daher, J.P. et al. Hum. Mol. Genet. 21, 2420–2431 (2012).
Herzig, M.C. et al. PLoS ONE 7, e36581 (2012).
Mazzulli, J.R. et al. Cell 146, 37–52 (2011).
Usenovic, M. et al. J. Neurosci. 32, 4240–4246 (2012).
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Yue, Z., Yang, X. Dangerous duet: LRRK2 and α-synuclein jam at CMA. Nat Neurosci 16, 375–377 (2013). https://doi.org/10.1038/nn.3361
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DOI: https://doi.org/10.1038/nn.3361
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