Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.
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This study was supported by grant 916.66.095 from the Netherlands Organization for Scientific Research ZON-MW VENI program. A.M. was supported from a VENI grant 016.115.196 from the Netherlands Organization for Scientific Research.
P.R.S. is an independent consultant for Medtronic Inc on educational matters and received travel grants from the company.
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Figee, M., Luigjes, J., Smolders, R. et al. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci 16, 386–387 (2013). https://doi.org/10.1038/nn.3344
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