Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Retooling spare parts: gene duplication and cognition

Nature Neuroscience volume 16, pages 6–8 (2013)Cite this article

Subjects

Two new studies provide experimental evidence of how ancient genomic duplications of synaptic genes provided the substrate for diversification that ultimately expanded vertebrate cognitive complexity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: How drift and selection can result in functional diversification.

Katie Vicari

References

  1. Gillespie, J.H. Population Genetics: A Concise Guide 2nd edn (Johns Hopkins University Press, 2004).

    Google Scholar 

  2. Tinbergen, N. Z. Tierpsychol. 20, 410–433 (1963).

    Article  Google Scholar 

  3. Conant, G.C. & Wolfe, K.H. Nat. Rev. Genet. 9, 938–950 (2008).

    Article  CAS  Google Scholar 

  4. Enard, W. et al. Cell 137, 961–971 (2009).

    Article  CAS  Google Scholar 

  5. Konopka, G. et al. Nature 462, 213–217 (2009).

    Article  CAS  Google Scholar 

  6. Nithianantharajah, J. et al. Nat. Neurosci. 16, 16–24 (2013).

    Article  CAS  Google Scholar 

  7. Robbins, T.W. et al. Dementia 5, 266–281 (1994).

    CAS  PubMed  Google Scholar 

  8. Bussey, T.J. et al. Neuropharmacology 62, 1191–1203 (2012).

    Article  CAS  Google Scholar 

  9. Ryan, T.J. et al. Nat. Neurosci. 16, 25–32 (2013).

    Article  CAS  Google Scholar 

  10. Young, J.W., Zhou, X. & Geyer, M.A. Current Topics in Behavioral Neurosciences Vol. 4 (ed. Swerdlow, N.R.) 391–433 (Springer, 2010).

    Google Scholar 

  11. Peñagarikano, O. & Geschwind, D.H. Trends Mol. Med. 18, 156–163 (2012).

    Article  Google Scholar 

  12. Won, H. et al. Nature 486, 261–265 (2012).

    Article  CAS  Google Scholar 

  13. Konopka, G. et al. Neuron 75, 601–617 (2012).

    Article  CAS  Google Scholar 

  14. Khaitovich, P. et al. PLoS Biol. 2, e132 (2004).

    Article  Google Scholar 

  15. Gottesman, I.I. & Gould, T. Am. J. Psychiatry 160, 636–645 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. T. Grant Belgard and Daniel H. Geschwind are at the Center for Autism Research and Treatment and the Program in Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA,

    T Grant Belgard

  2. Daniel H. Geschwind is in the Departments of Human Genetics and Neurology, University of California, Los Angeles, Los Angeles, California, USA.,

    Daniel H Geschwind

Authors
  1. T Grant Belgard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel H Geschwind
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel H Geschwind.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belgard, T., Geschwind, D. Retooling spare parts: gene duplication and cognition. Nat Neurosci 16, 6–8 (2013). https://doi.org/10.1038/nn.3292

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3292

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing