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How do environments talk to genes?

A report elucidates the widely recognized, but poorly understood, concept of gene-environment interaction, finding a molecular mechanism in the case of post-traumatic stress disorder: demethylation of a glucocorticoid response element in the stress response regulator FKBP5 that depends on both the risk allele and childhood trauma.

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Figure 1: A model mechanism for gene-environment interaction.


  1. Caspi, A. et al. Science 301, 386–389 (2003).

    CAS  Article  Google Scholar 

  2. Klengel, T. Nat. Neurosci. 15, 33–41 (2012).

    Google Scholar 

  3. Weaver, I.C. et al. Nat. Neurosci. 7, 847–854 (2004).

    CAS  Article  Google Scholar 

  4. Binder, E.B. et al. J. Am. Med. Assoc. 299, 1291–1305 (2008).

    CAS  Article  Google Scholar 

  5. D'Alessio, A.C., Weaver, I.C. & Szyf, M. Mol. Cell. Biol. 27, 7462–7474 (2007).

    CAS  Article  Google Scholar 

  6. Szyf, M. Clin. Genet. 81, 341–349 (2012).

    CAS  Article  Google Scholar 

  7. Razin, A. & Szyf, M. Biochim. Biophys. Acta 782, 331–342 (1984).

    CAS  Article  Google Scholar 

  8. Wang, D. et al. PLoS ONE 7, e39501 (2012).

    CAS  Article  Google Scholar 

  9. Yehuda, R. et al. Biol. Psychiatry 66, 708–711 (2009).

    CAS  Article  Google Scholar 

  10. Uddin, M. et al. Proc. Natl. Acad. Sci. USA 107, 9470–9475 (2010).

    CAS  Article  Google Scholar 

  11. Uddin, M. et al. Dis. Markers 30, 111–121 (2011).

    CAS  Article  Google Scholar 

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Correspondence to Moshe Szyf.

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Szyf, M. How do environments talk to genes?. Nat Neurosci 16, 2–4 (2013).

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