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How do environments talk to genes?

A report elucidates the widely recognized, but poorly understood, concept of gene-environment interaction, finding a molecular mechanism in the case of post-traumatic stress disorder: demethylation of a glucocorticoid response element in the stress response regulator FKBP5 that depends on both the risk allele and childhood trauma.

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Figure 1: A model mechanism for gene-environment interaction.

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Correspondence to Moshe Szyf.

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Szyf, M. How do environments talk to genes?. Nat Neurosci 16, 2–4 (2013). https://doi.org/10.1038/nn.3286

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