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Neuroligins help dendrites keep up with the Joneses

A study reconciling contradictory in vitro and in vivo data on neuroligins in synapse formation shows that cell-to-cell variability in neuroligin-1 levels, mediating competition for presynaptic inputs, regulates synapse density.

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Figure 1: Relative abundance of NL1 determines spine density through competitive cell-cell interactions.


  1. Kwon, H.B. et al. Nat. Neurosci. 15, 1667–1674 (2012).

    Article  CAS  Google Scholar 

  2. Scheiffele, P., Fan, J., Choih, J., Fetter, R. & Serafini, T. Cell 101, 657–669 (2000).

    Article  CAS  Google Scholar 

  3. Chubykin, A.A. et al. Neuron 54, 919–931 (2007).

    Article  CAS  Google Scholar 

  4. Chih, B., Engelman, H. & Scheiffele, P. Science 307, 1324–1328 (2005).

    Article  CAS  Google Scholar 

  5. Südhof, T.C. Nature 455, 903–911 (2008).

    Article  Google Scholar 

  6. Barrow, S.L. et al. Neural Dev. 4, 17 (2009).

    Article  Google Scholar 

  7. Varoqueaux, F. et al. Neuron 51, 741–754 (2006).

    Article  CAS  Google Scholar 

  8. Kim, J. et al. Proc. Natl. Acad. Sci. USA 105, 9087–9092 (2008).

    Article  CAS  Google Scholar 

  9. Blundell, J. et al. J. Neurosci. 30, 2115–2129 (2010).

    Article  CAS  Google Scholar 

  10. Kwon, H.B. & Sabatini, B.L. Nature 474, 100–104 (2011).

    Article  CAS  Google Scholar 

  11. Buffelli, M. et al. Nature 424, 430–434 (2003).

    Article  CAS  Google Scholar 

  12. Burrone, J., O'Byrne, M. & Murthy, V.N. Nature 420, 414–418 (2002).

    Article  CAS  Google Scholar 

  13. McClelland, A.C., Hruska, M., Coenen, A.J., Henkemeyer, M. & Dalva, M.B. Proc. Natl. Acad. Sci. USA 107, 8830–8835 (2010).

    Article  CAS  Google Scholar 

  14. Soler-Llavina, G.J., Fuccillo, M.V., Ko, J., Sudhof, T.C. & Malenka, R.C. Proc. Natl. Acad. Sci. USA 108, 16502–16509 (2011).

    Article  CAS  Google Scholar 

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Correspondence to A Kimberley McAllister.

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Barrow, S., McAllister, A. Neuroligins help dendrites keep up with the Joneses. Nat Neurosci 15, 1609–1611 (2012).

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