Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Impaired adult myelination in the prefrontal cortex of socially isolated mice

Abstract

Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Prolonged social isolation of adult mice induces hypomyelination in PFC.
Figure 2: Prolonged social isolation of adult mice decreases myelin gene products and heterochromatin formation.
Figure 3: Short-term isolation is sufficient to induce chromatin changes and reduce myelin thickness in both adult and juvenile mice.

References

  1. Kikusui, T., Kiyokawa, Y. & Mori, Y. Brain Res. 1133, 115–122 (2007).

    Article  CAS  Google Scholar 

  2. Makinodan, M., Rosen, K.M., Ito, S. & Corfas, G. Science 337, 1357–1360 (2012).

    Article  CAS  Google Scholar 

  3. Fuster, J.M. J. Neurocytol. 31, 373–385 (2002).

    Article  Google Scholar 

  4. Wallace, D.L. et al. Nat. Neurosci. 12, 200–209 (2009).

    Article  CAS  Google Scholar 

  5. Pillai, A.M. et al. J. Neurosci. Res. 87, 1773–1793 (2009).

    Article  CAS  Google Scholar 

  6. Shen, S. et al. Nat. Neurosci. 11, 1024–1034 (2008).

    Article  CAS  Google Scholar 

  7. Shen, S., Li, J. & Casaccia-Bonnefil, P. J. Cell Biol. 169, 577–589 (2005).

    Article  CAS  Google Scholar 

  8. Ye, F. et al. Nat. Neurosci. 12, 829–838 (2009).

    Article  CAS  Google Scholar 

  9. He, Y. et al. Neuron 55, 217–230 (2007).

    Article  CAS  Google Scholar 

  10. Regenold, W.T. et al. Bipolar Disord. 8, 188–195 (2006).

    Article  Google Scholar 

  11. Fields, R.D. Trends Neurosci. 31, 361–370 (2008).

    Article  CAS  Google Scholar 

  12. Sokolov, B.P. Int. J. Neuropsychopharmacol. 10, 547–555 (2007).

    Article  CAS  Google Scholar 

  13. Sexton, C.E., Mackay, C.E. & Ebmeier, K.P. Biol. Psychiatry 66, 814–823 (2009).

    Article  Google Scholar 

  14. Rajkowska, G. et al. Biol. Psychiatry 45, 1085–1098 (1999).

    Article  CAS  Google Scholar 

  15. Chari, D.M. et al. J. Neurosci. Res. 83, 594–605 (2006).

    Article  CAS  Google Scholar 

  16. Arnett, P.A., Barwick, F.H. & Beeney, J.E. J. Int. Neuropsychol. Soc. 14, 691–724 (2008).

    Article  Google Scholar 

  17. Berton, O. et al. Science 311, 864–868 (2006).

    Article  CAS  Google Scholar 

  18. Marcus, J. et al. Glia 53, 372–381 (2006).

    Article  CAS  Google Scholar 

  19. Shroff, S.M. et al. J. Neurosci. Res. 87, 3403–3414 (2009).

    Article  CAS  Google Scholar 

  20. Abramoff, M.D., Magalhães, P.J. & Ram, S.J. Biophotonics Int. 11, 36–42 (2004).

    Google Scholar 

Download references

Acknowledgements

We thank A. Sharp, P. Garg and J. Huynh for help with statistical analysis and multiple correction tests. This work was funded by the US National Institutes of Health (R37-NS42925-10 to P.C. and P50-MH96890 to E.J.N.), a Center core grant to the Virginia Commonwealth University Microscopy Facility (5P30NS047463) and the National Multiple Sclerosis Society (FG1874-A-1 to J.L.).

Author information

Authors and Affiliations

Authors

Contributions

J.L. and K.D. performed the experiments, contributed to data acquisition and analysis, and wrote the paper. X.P., D.K., M.K.L. and J.K. assisted with data acquisition. D.M.D. and V.V. provided behavioral analysis. J.M.D. and J.D. contributed to the ultrastructural analysis. J.D. and E.J.N. contributed to data interpretation and wrote the paper. P.C. ideated and directed the project, analyzed the data and wrote the paper.

Corresponding author

Correspondence to Patrizia Casaccia.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–5 and Supplementary Table 1 (PDF 6873 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Liu, J., Dietz, K., DeLoyht, J. et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci 15, 1621–1623 (2012). https://doi.org/10.1038/nn.3263

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3263

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing