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Impaired adult myelination in the prefrontal cortex of socially isolated mice

Nature Neuroscience volume 15, pages 16211623 (2012) | Download Citation

Abstract

Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes of the prefrontal cortex (PFC) and impaired adult myelination. Social re-integration was sufficient to normalize behavioral and transcriptional changes. Short periods of isolation affected chromatin and myelin, but did not induce behavioral changes. Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity.

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Acknowledgements

We thank A. Sharp, P. Garg and J. Huynh for help with statistical analysis and multiple correction tests. This work was funded by the US National Institutes of Health (R37-NS42925-10 to P.C. and P50-MH96890 to E.J.N.), a Center core grant to the Virginia Commonwealth University Microscopy Facility (5P30NS047463) and the National Multiple Sclerosis Society (FG1874-A-1 to J.L.).

Author information

Author notes

    • Mary Kay Lobo
    •  & David M Dietz

    Present addresses: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA (M.K.L.), Department of Pharmacology and Toxicology, University of Buffalo School of Medicine, Buffalo, New York, USA (D.M.D.).

    • Jia Liu
    •  & Karen Dietz

    These authors contributed equally to this work.

Affiliations

  1. Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA.

    • Jia Liu
    • , Karen Dietz
    • , Xiomara Pedre
    • , Dipti Kelkar
    • , Jasbir Kaur
    • , Vincent Vialou
    • , Mary Kay Lobo
    • , David M Dietz
    • , Eric J Nestler
    •  & Patrizia Casaccia
  2. Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.

    • Jacqueline M DeLoyht
    •  & Jeffrey Dupree

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Contributions

J.L. and K.D. performed the experiments, contributed to data acquisition and analysis, and wrote the paper. X.P., D.K., M.K.L. and J.K. assisted with data acquisition. D.M.D. and V.V. provided behavioral analysis. J.M.D. and J.D. contributed to the ultrastructural analysis. J.D. and E.J.N. contributed to data interpretation and wrote the paper. P.C. ideated and directed the project, analyzed the data and wrote the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Patrizia Casaccia.

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    Supplementary Figures 1–5 and Supplementary Table 1

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DOI

https://doi.org/10.1038/nn.3263

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