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The medial entorhinal cortex keeps Up

A study reveals that medial entorhinal cortex layer III spiking dynamics shape the neocortical-hippocampal dialog during Up-Down state fluctuations in slow-wave sleep that may contribute to memory consolidation.

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Figure 1: MEC layer III neurons exhibit persistent Up states.

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Correspondence to David Dupret or Jozsef Csicsvari.

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Dupret, D., Csicsvari, J. The medial entorhinal cortex keeps Up. Nat Neurosci 15, 1471–1472 (2012). https://doi.org/10.1038/nn.3245

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