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Knockout punch: cardiolipin oxidation in trauma

During brain injury, mechanical injuries to neural cells initiate an apoptotic cascade through cardiolipin oxidation. Mitochondrially targeted electron scavenger compounds block this process, suggesting new therapeutic avenues.

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Figure 1: Blocking cardiolipin peroxidation during acute brain injury prevents apoptotic cell death.


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Correspondence to Gilbert Di Paolo.

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Chan, R., Di Paolo, G. Knockout punch: cardiolipin oxidation in trauma. Nat Neurosci 15, 1325–1327 (2012).

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