During brain injury, mechanical injuries to neural cells initiate an apoptotic cascade through cardiolipin oxidation. Mitochondrially targeted electron scavenger compounds block this process, suggesting new therapeutic avenues.
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Chan, R., Di Paolo, G. Knockout punch: cardiolipin oxidation in trauma. Nat Neurosci 15, 1325–1327 (2012). https://doi.org/10.1038/nn.3222
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DOI: https://doi.org/10.1038/nn.3222