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Target practice: HDAC inhibitors for schizophrenia

Nature Neuroscience volume 15, pages 1180–1181 (2012)Cite this article

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A report in this issue suggests that inhibiting histone deacetylase 2 (HDAC2) could be therapeutic in schizophrenia. Targeting chromatin remodeling in adults to treat a chronic brain disorder is not, however, likely to be easy.

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Figure 1: Epigenetic regulation of mGlu2 transcription.

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  1. Steven E. Hyman is at the Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.,

    Steven E Hyman

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  1. Steven E Hyman
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Correspondence to Steven E Hyman.

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S.E.H. is a Novartis Science Board Member.

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Hyman, S. Target practice: HDAC inhibitors for schizophrenia. Nat Neurosci 15, 1180–1181 (2012). https://doi.org/10.1038/nn.3200

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