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DNA methylation in cognition comes of age

A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.

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Figure 1: Elevating Dnmt3a2 can promote memory formation.

Marina Corral

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Correspondence to Li-Huei Tsai.

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Su, S., Tsai, LH. DNA methylation in cognition comes of age. Nat Neurosci 15, 1061–1062 (2012). https://doi.org/10.1038/nn.3169

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