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DNA methylation in cognition comes of age

Nature Neuroscience volume 15, pages 1061–1062 (2012)Cite this article

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A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.

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Figure 1: Elevating Dnmt3a2 can promote memory formation.

Marina Corral

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Authors and Affiliations

  1. Department of Brain and Cognitive Sciences, Susan C. Su and Li-Huei Tsai are at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.,

    Susan C Su & Li-Huei Tsai

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  1. Susan C Su
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  2. Li-Huei Tsai
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Correspondence to Li-Huei Tsai.

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Su, S., Tsai, LH. DNA methylation in cognition comes of age. Nat Neurosci 15, 1061–1062 (2012). https://doi.org/10.1038/nn.3169

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