Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

New game for hunger neurons

Nature Neuroscience volume 15, pages 1060–1061 (2012)Cite this article

Subjects

Hypothalamic neurons that express agouti-related protein have been thought to regulate appetite by counteracting the melanocortin signaling pathway. Evidence now indicates that these neurons can also modulate dopamine signaling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Reduced activity of AgRP neurons facilitates VTA dopamine neuron activation of the nucleus accumbens.

Marina Corral

References

  1. Dietrich, M.O. et al. Nat. Neurosci. 15, 1108–1110 (2012).

    Article  CAS  Google Scholar 

  2. Morton, G.J. et al. Nature 443, 289–295 (2006).

    Article  CAS  Google Scholar 

  3. Dietrich, M.O. et al. J. Neurosci. 30, 11815–11825 (2010).

    Article  CAS  Google Scholar 

  4. Johnson, P.M. & Kenny, R.J. Nat. Neurosci. 13, 635–641 (2010).

    Article  CAS  Google Scholar 

  5. Broberger, C. et al. Proc. Natl. Acad. Sci. USA 95, 15043–15048 (1998).

    Article  CAS  Google Scholar 

  6. Cone, R.D. Nat. Neurosci. 8, 571–578 (2005).

    Article  CAS  Google Scholar 

  7. Aponte, Y., Atasoy, D. & Sternson, S.M. Nat. Neurosci. 14, 351–355 (2011).

    Article  CAS  Google Scholar 

  8. Krashes, M.J. et al. J. Clin. Invest. 121, 1424–1428 (2011).

    Article  CAS  Google Scholar 

  9. Wu, Q., Boyle, M.P. & Palmiter, R.D. Cell 137, 1225–1234 (2009).

    Article  Google Scholar 

  10. Gropp, E. et al. Nat. Neurosci. 8, 1289–1291 (2005).

    Article  CAS  Google Scholar 

  11. Luquet, S. et al. Science 310, 683–685 (2005).

    Article  CAS  Google Scholar 

  12. Qian, S. et al. Mol. Cell. Biol. 22, 5027–5035 (2002).

    Article  CAS  Google Scholar 

  13. Tong, Q. et al. Nat. Neurosci. 11, 998–1000 (2008).

    Article  CAS  Google Scholar 

  14. Israel, D.D. et al. Endocrinology 153, 2408–2419 (2012).

    Article  CAS  Google Scholar 

  15. Wu, Q., Whiddon, B.B. & Palmiter, R.D. Proc. Natl. Acad. Sci. USA 109, 3155–3160 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Richard D. Palmiter is at the Howard Hughes Medical Institute and Department of Biochemistry University of Washington, Seattle, Washington, USA.,

    Richard D Palmiter

Authors
  1. Richard D Palmiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard D Palmiter.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Palmiter, R. New game for hunger neurons. Nat Neurosci 15, 1060–1061 (2012). https://doi.org/10.1038/nn.3167

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3167

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing