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On the scent of mitochondrial calcium

Odorants are now shown to elevate mitochondrial Ca2+ in sensory neurons; moreover, blocking this Ca2+ sequestration impairs dynamic range. Acute stimulation rapidly recruits mitochondria from the soma to the dendritic knob.

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Figure 1: Schematic representation of Ca2+ signaling mechanisms in cilia and dendritic knob of an OSN.

Katie Vicari

References

  1. Fluegge, D. et al. Nat. Neurosci. 15, 754–762 (2012).

    Article  CAS  Google Scholar 

  2. Menini, A. Curr. Opin. Neurobiol. 9, 419–426 (1999).

    Article  CAS  Google Scholar 

  3. Zufall, F. & Leinders-Zufall, T. Chem. Senses 25, 473–481 (2000).

    Article  CAS  Google Scholar 

  4. Matthews, H.R. & Reisert, J. Curr. Opin. Neurobiol. 13, 469–475 (2003).

    Article  CAS  Google Scholar 

  5. Kleene, S.J. Chem. Senses 33, 839–859 (2008).

    Article  CAS  Google Scholar 

  6. Kurahashi, T. & Shibuya, T. Brain Res. 515, 261–268 (1990).

    Article  CAS  Google Scholar 

  7. Zufall, F., Shepherd, G.M. & Firestein, S. Proc. Biol. Sci. 246, 225–230 (1991).

    Article  CAS  Google Scholar 

  8. Leinders-Zufall, T., Greer, C.A., Shepherd, G.M. & Zufall, F. J. Neurosci. 18, 5630–5639 (1998).

    Article  CAS  Google Scholar 

  9. Leinders-Zufall, T., Ma, M. & Zufall, F. J. Neurosci. 19, RC19 (1999).

    Article  CAS  Google Scholar 

  10. Reisert, J. & Matthews, H.R. J. Gen. Physiol. 112, 529–535 (1998).

    Article  CAS  Google Scholar 

  11. Stephan, A.B. et al. Nat. Neurosci. 15, 131–137 (2012).

    Article  CAS  Google Scholar 

  12. Billig, G.M., Pal, B., Fidzinski, P. & Jentsch, T.J. Nat. Neurosci. 14, 763–769 (2011).

    Article  CAS  Google Scholar 

  13. Zufall, F., Leinders-Zufall, T. & Greer, C.A. J. Neurophysiol. 83, 501–512 (2000).

    Article  CAS  Google Scholar 

  14. Drago, I., Pizzo, P. & Pozzan, T. EMBO J. 30, 4119–4125 (2011).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Frank Zufall.

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Zufall, F. On the scent of mitochondrial calcium. Nat Neurosci 15, 653–654 (2012). https://doi.org/10.1038/nn.3090

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