Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

On the scent of mitochondrial calcium

Odorants are now shown to elevate mitochondrial Ca2+ in sensory neurons; moreover, blocking this Ca2+ sequestration impairs dynamic range. Acute stimulation rapidly recruits mitochondria from the soma to the dendritic knob.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Schematic representation of Ca2+ signaling mechanisms in cilia and dendritic knob of an OSN.

Katie Vicari


  1. Fluegge, D. et al. Nat. Neurosci. 15, 754–762 (2012).

    Article  CAS  Google Scholar 

  2. Menini, A. Curr. Opin. Neurobiol. 9, 419–426 (1999).

    Article  CAS  Google Scholar 

  3. Zufall, F. & Leinders-Zufall, T. Chem. Senses 25, 473–481 (2000).

    Article  CAS  Google Scholar 

  4. Matthews, H.R. & Reisert, J. Curr. Opin. Neurobiol. 13, 469–475 (2003).

    Article  CAS  Google Scholar 

  5. Kleene, S.J. Chem. Senses 33, 839–859 (2008).

    Article  CAS  Google Scholar 

  6. Kurahashi, T. & Shibuya, T. Brain Res. 515, 261–268 (1990).

    Article  CAS  Google Scholar 

  7. Zufall, F., Shepherd, G.M. & Firestein, S. Proc. Biol. Sci. 246, 225–230 (1991).

    Article  CAS  Google Scholar 

  8. Leinders-Zufall, T., Greer, C.A., Shepherd, G.M. & Zufall, F. J. Neurosci. 18, 5630–5639 (1998).

    Article  CAS  Google Scholar 

  9. Leinders-Zufall, T., Ma, M. & Zufall, F. J. Neurosci. 19, RC19 (1999).

    Article  CAS  Google Scholar 

  10. Reisert, J. & Matthews, H.R. J. Gen. Physiol. 112, 529–535 (1998).

    Article  CAS  Google Scholar 

  11. Stephan, A.B. et al. Nat. Neurosci. 15, 131–137 (2012).

    Article  CAS  Google Scholar 

  12. Billig, G.M., Pal, B., Fidzinski, P. & Jentsch, T.J. Nat. Neurosci. 14, 763–769 (2011).

    Article  CAS  Google Scholar 

  13. Zufall, F., Leinders-Zufall, T. & Greer, C.A. J. Neurophysiol. 83, 501–512 (2000).

    Article  CAS  Google Scholar 

  14. Drago, I., Pizzo, P. & Pozzan, T. EMBO J. 30, 4119–4125 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Frank Zufall.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zufall, F. On the scent of mitochondrial calcium. Nat Neurosci 15, 653–654 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing