Abstract
Gamma oscillations in the dentate gyrus and hippocampal CA3 show variable coherence in vivo, but the mechanisms and relevance for information flow are unknown. We found that carbachol-induced oscillations in rat CA3 have biphasic phase-response curves, consistent with the ability to couple with oscillations in afferent projections. Differences in response to stimulation of either the intrinsic feedback circuit or the dentate gyrus were well described by varying an impulse vector in a two-dimensional dynamical system, representing the relative input to excitatory and inhibitory neurons. Responses to sinusoidally modulated optogenetic stimulation confirmed that the CA3 network oscillation can entrain to periodic inputs, with a steep dependence of entrainment phase on input frequency. CA3 oscillations are therefore suited to coupling with oscillations in the dentate gyrus over a broad range of frequencies.
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Acknowledgements
We are grateful to N. Burgess for comments on the manuscript and to K. Deisseroth for the ChR2 plasmid. This work was supported by the Wellcome Trust, the European Research Council, the Brain Research Trust and the Guarantors of Brain.
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T.A. and D.M.K. designed the experiments and wrote the manuscript. T.A. and E.F. conducted the electrical stimulation rephasing experiments. I.O. conducted the intracellular recording experiments. T.A. and L.M. conducted the optogenetic experiments. T.A. performed the computational modeling and data analysis.
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Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–4 (PDF 2679 kb)
Supplementary Video 1a
Rephasing Animations: Weak alveus stimulation (MOV 2747 kb)
Supplementary Video 1b
Rephasing Animations: Strong alveus stimulation (MOV 2554 kb)
Supplementary Video 1c
Rephasing Animations: Weak dentate stimulation (MOV 2748 kb)
Supplementary Video 1d
Rephasing Animations: Weak dentate stimulation (MOV 2393 kb)
Supplementary Video 2a
Intracellular current trajectory animations: alveus stimulation (MOV 459 kb)
Supplementary Video 2b
Intracellular current trajectory animations: dentate stimulation (MOV 1503 kb)
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Akam, T., Oren, I., Mantoan, L. et al. Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling. Nat Neurosci 15, 763–768 (2012). https://doi.org/10.1038/nn.3081
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DOI: https://doi.org/10.1038/nn.3081
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