Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Abstract

Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Hypothalamic proliferative zone.
Figure 2: The median eminence is a neurogenic niche.
Figure 3: Median eminence neurogenesis regulates metabolism.

References

  1. Kokoeva, M.V., Yin, H. & Flier, J.S. Science 310, 679–683 (2005).

    Article  CAS  Google Scholar 

  2. Pierce, A.A. & Xu, A.W. J. Neurosci. 30, 723–730 (2010).

    Article  CAS  Google Scholar 

  3. Xu, Y. et al. Exp. Neurol. 192, 251–264 (2005).

    Article  CAS  Google Scholar 

  4. Mathew, T.C. Anat. Histol. Embryol. 37, 9–18 (2008).

    CAS  PubMed  Google Scholar 

  5. Rodríguez, E.M. et al. Int. Rev. Cytol. 247, 89–164 (2005).

    Article  Google Scholar 

  6. Shimogori, T. et al. Nat. Neurosci. 13, 767–775 (2010).

    Article  CAS  Google Scholar 

  7. Miller, I., Ronnett, G.V., Moran, T.H. & Aja, S. Neuroreport 15, 925–929 (2004).

    Article  CAS  Google Scholar 

  8. Cowley, M.A. et al. Nature 411, 480–484 (2001).

    Article  CAS  Google Scholar 

  9. Simerly, R.B. Physiol. Behav. 94, 79–89 (2008).

    Article  CAS  Google Scholar 

  10. Balordi, F. & Fishell, G. J. Neurosci. 27, 14248–14259 (2007).

    Article  CAS  Google Scholar 

  11. Srinivas, S. et al. BMC Dev. Biol. 1, 4 (2001).

    Article  CAS  Google Scholar 

  12. Masahira, N. et al. Dev. Biol. 293, 358–369 (2006).

    Article  CAS  Google Scholar 

  13. Ford, E.C. et al. Radiat. Res. 175, 774–783 (2011).

    Article  CAS  Google Scholar 

  14. Matinfar, M. et al. Med. Image Comput. Comput. Assist. Interv. 10, 926–934 (2007).

    PubMed  Google Scholar 

  15. D'Avella, D. et al. J. Neurosurg. 81, 774–779 (1994).

    Article  CAS  Google Scholar 

  16. Abercrombie, M. Anat. Rec. 94, 239–247 (1946).

    Article  CAS  Google Scholar 

  17. Lusk, G. The Elements of the Science of Nutrition 4th edn. (W.B. Saunders, Philadelphia, 1928).

Download references

Acknowledgements

We thank J. Nathans, S. Hattar, N. Gaiano, P. Achanta, C. Montojo, D. McClellan, T. Shimogori, T. Moran, E. Newman, M. Taylor and W. Yap for comments on the manuscript. We also thank M. Bonaguidi, C. Montojo, J. Reyes, M. Armour, E. Velarde, N. Forbes-McBean, W.F. Han and the Johns Hopkins School of Medicine Microscope Facility for technical advice and assistance. This work was supported by US National Institutes of Health grant F31 NS063550 and an NSF Graduate Fellowship (to D.A.L.), a Basil O'Connor Starter Scholar Award and grants from the Klingenstein Fund and NARSAD (to S.B.). S.B. is a W.M. Keck Distinguished Young Scholar in Medical Research.

Author information

Authors and Affiliations

Authors

Contributions

D.A.L. and S.B. designed experiments. D.A.L., J.L.B., T.P., V.T., J.S., H.W., A.M.A., E.F., V.C. and S.A. performed experiments. D.A.L., J.L.B., T.P., A.M.A., V.C., S.A. and S.B. analyzed data. F.B., H.T. and G.F. contributed transgenic mice. D.A.L. and S.B. wrote the manuscript.

Corresponding author

Correspondence to Seth Blackshaw.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–7 and Supplementary Tables 1 and 2 (PDF 2410 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, D., Bedont, J., Pak, T. et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci 15, 700–702 (2012). https://doi.org/10.1038/nn.3079

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3079

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing