A knock-in mouse mimicking a MeCP2 mutation found in human Rett syndrome recapitulates disease features, including progressive motor and cognitive impairments—and correlations emerge between MeCP2 dosage in mice and phenotype.
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Chao, HT., Zoghbi, H. MeCP2: only 100% will do. Nat Neurosci 15, 176–177 (2012). https://doi.org/10.1038/nn.3027
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DOI: https://doi.org/10.1038/nn.3027
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