A study finds that the voltage-gated K+ channel KCNQ4 is expressed in a subset of rapidly adapting, low-threshold mechanoreceptors, where it shapes the response profile to dynamic tactile stimuli.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Heidenreich, M. et al. Nat Neurosci. 15, 138–145 (2011).
Brown, D.A. & Passmore, G.M. Br. J. Pharmacol. 156, 1185–1195 (2009).
Kharkovets, T. et al. EMBO J. 25, 642–652 (2006).
Neyroud, N. et al. Nat. Genet. 15, 186–189 (1997).
Kubisch, C. et al. Cell 96, 437–446 (1999).
Mencía, A. et al. Hum. Genet. 123, 41–53 (2008).
Baek, J.I. et al. Biochim. Biophys. Acta 1812, 536–543 (2011).
Kim, H.J., Lv, P., Sihn, C.R. & Yamoah, E.N. J. Biol. Chem. 286, 1517–1527 (2011).
Lv, P., Wei, D. & Yamoah, E.N. J. Biol. Chem. 285, 34699–34707 (2010).
Passmore, G.M. et al. J. Neurosci. 23, 7227–7236 (2003).
Talbot, W.H., Darian-Smith, I., Kornhuber, H.H. & Mountcastle, V.B. J. Neurophysiol. 31, 301–334 (1968).
Chen, X., Green, P.G. & Levine, J.D. Pain 151, 460–466 (2010).
Chung, H.J., Jan, Y.N. & Jan, L.Y. Proc. Natl. Acad. Sci. USA 103, 8870–8875 (2006).
Acknowledgements
This work was supported by the US National Institutes of Health (NS054902) and the Blaustein Pain Research Fund.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Munns, C., Caterina, M. Tune in to KCNQ. Nat Neurosci 15, 8–10 (2012). https://doi.org/10.1038/nn.3012
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.3012