Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Relax, you won't feel the pain

Nature Neuroscience volume 14, pages 1496–1497 (2011)Cite this article

Subjects

Variations in the arginine vasopressin receptor gene, AVPR1A, are shown to be associated with pain sensitivity in a stress- and sex-specific manner in both mice and men.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model of how Avpr1a, stress and sex modulate pain sensitivity.

References

  1. Mogil, J.S. et al. Nat. Neurosci. 14, 1569–1573 (2011).

    Article  CAS  Google Scholar 

  2. Bodnar, R.J. Ann. NY Acad. Sci. 467, 345–360 (1986).

    Article  CAS  Google Scholar 

  3. Butler, R.K. & Finn, D.P. Prog. Neurobiol. 88, 184–202 (2009).

    Article  CAS  Google Scholar 

  4. Randich, A. & Maixner, W. Neurosci. Biobehav. Rev. 8, 343–367 (1984).

    Article  CAS  Google Scholar 

  5. Mogil, J.S. et al. Proc. Natl. Acad. Sci. USA 100, 4867–4872 (2003).

    Article  CAS  Google Scholar 

  6. Tegeder, I. et al. Nat. Med. 12, 1269–1277 (2006).

    Article  CAS  Google Scholar 

  7. Costigan, M. et al. Brain 133, 2519–2527 (2010).

    Article  Google Scholar 

  8. Neely, G.G. et al. Cell 143, 628–638 (2010).

    Article  CAS  Google Scholar 

  9. Diatchenko, L. et al. Hum. Mol. Genet. 14, 135–143 (2005).

    Article  CAS  Google Scholar 

  10. Nackley, A.G. et al. Pain 128, 199–208 (2006).

    Article  Google Scholar 

  11. Tchivileva, I.E. et al. Pharmacogenet. Genomics 20, 239–248 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Diatchenko, L., Nackley, A.G., Tchivileva, I.E., Shabalina, S.A. & Maixner, W. Trends Genet. 23, 605–613 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tim Wiltshire is in the Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA.,

    Tim Wiltshire

  2. William Maixner and Luda Diatchenko are at the Center for Neurosensory Disorders at the University of North Carolina, Chapel Hill, North Carolina, USA.,

    William Maixner & Luda Diatchenko

Authors
  1. Tim Wiltshire
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William Maixner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luda Diatchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tim Wiltshire.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wiltshire, T., Maixner, W. & Diatchenko, L. Relax, you won't feel the pain. Nat Neurosci 14, 1496–1497 (2011). https://doi.org/10.1038/nn.2987

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.2987

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing