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Receptors in (e)motion

A study finds that recall of fear-provoking memory changes the surface levels of AMPA receptors in the dorsal hippocampus. Inhibition of AMPA receptor trafficking strengthens the memory and results in excessive fear.

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Figure 1: Experimental protocols used to test the role of AMPAR trafficking in memory reconsolidation and extinction after contextual fear conditioning.

Katie Vicari

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Correspondence to Jelena Radulovic.

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The authors declare no competing financial interests.

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Radulovic, J., Tronson, N. Receptors in (e)motion. Nat Neurosci 14, 1222–1224 (2011). https://doi.org/10.1038/nn.2938

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