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Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche

Nature Neuroscience volume 14, pages 14071409 (2011) | Download Citation

Abstract

Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.

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Acknowledgements

We thank members of the Wadiche laboratory and A. Tzingounis for helpful comments, and A. Margolies and C. Zhao for technical assistance. This work was supported by grants from the US National Institutes of Health (5T32GM008111, 5R01NS064025 and 2P30NS047466).

Author information

Affiliations

  1. Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.

    • Sean J Markwardt
    • , Cristina V Dieni
    • , Jacques I Wadiche
    •  & Linda Overstreet-Wadiche

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Contributions

All of the authors contributed to each aspect of this work.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Linda Overstreet-Wadiche.

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DOI

https://doi.org/10.1038/nn.2935

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