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Sleep and waking modulate spine turnover in the adolescent mouse cortex

Nature Neuroscience volume 14, pages 14181420 (2011) | Download Citation

Abstract

Cortical development involves synaptic formation and elimination. Although synaptogenesis predominates in the early stages and pruning in the later stages, the two processes are thought to happen concurrently. In adults, synaptic strength is modulated by behavioral state, and we asked whether synaptic remodeling may be affected by sleep and waking states. Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss.

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Acknowledgements

This study was supported by a US National Institutes of Health Director's Pioneer award (to G.T.) and the National Institute of Mental Health (1R01MH091326 to G.T. and C.C.).

Author information

Author notes

    • Stephanie Maret
    •  & Ugo Faraguna

    These authors contributed equally to this work.

Affiliations

  1. Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA.

    • Stephanie Maret
    • , Ugo Faraguna
    • , Aaron B Nelson
    • , Chiara Cirelli
    •  & Giulio Tononi
  2. Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin, USA.

    • Aaron B Nelson

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Contributions

C.C. and G.T. designed the experiments, analyzed the data and wrote the paper. S.M. and U.F. performed the experiments, analyzed the data and contributed to the manuscript. A.B.N. gathered EEG pilot data.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Chiara Cirelli or Giulio Tononi.

Supplementary information

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    Supplementary Text and Figures

    Supplementary Figures 1–3 and Supplementary Discussion and Supplementary Results

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DOI

https://doi.org/10.1038/nn.2934

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