The sustained metabolic activation of the brain's default-mode network is thought to render the system vulnerable to Alzheimer's disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
Scientific Reports Open Access 06 October 2016
-
Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders
Cell and Tissue Research Open Access 19 May 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bero, A.W. et al. Nat. Neurosci. 14, 750–756 (2011)
Raichle, M.E. et al. Proc. Natl. Acad. Sci. USA 98, 676–682 (2001).
Buckner, R.L., Andrews-Hanna, J.R. & Schacter, D.L. Ann. NY Acad. Sci. 1124, 1–38 (2008).
Broyd, S.J. et al. Neurosci. Biobehav. Rev. 33, 279–296 (2009).
Hardy, J. & Selkoe, D.J. Science 297, 353–356 (2002).
Buckner, R.L. et al. J. Neurosci. 25, 7709–7717 (2005).
Golde, T.E., Schneider, L.S. & Koo, E.H. Neuron 69, 203–213 (2011).
Flicker, L. J. Alzheimers Dis. 20, 803–811 (2010).
Hauw, J.J., Hausser-Hauw, C., De Girolami, U., Hasboun, D. & Seilhean, D. J. Neuropathol. Exp. Neurol. 70, 243–252 (2011).
Vyazovskiy, V.V., Cirelli, C., Pfister-Genskow, M., Faraguna, U. & Tononi, G. Nat. Neurosci. 11, 200–208 (2008).
Kang, J.E. et al. Science 326, 1005–1007 (2009).
Noebels, J. Epilepsia 52 suppl. 1, 39–46 (2011).
Callahan, M.J. et al. Am. J. Pathol. 158, 1173–1177 (2001).
Corder, E.H. et al. Ann. NY Acad. Sci. 1019, 24–28 (2004).
Meyer-Luehmann, M. et al. Science 313, 1781–1784 (2006).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Walker, L., Jucker, M. Amyloid by default. Nat Neurosci 14, 669–670 (2011). https://doi.org/10.1038/nn.2853
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2853
This article is cited by
-
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
Scientific Reports (2016)
-
Cystine oligomers successfully attached to peptide cysteine-rich fibrils
Frontiers of Chemical Science and Engineering (2016)
-
Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders
Cell and Tissue Research (2013)
