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Differential coupling of visual cortex with default or frontal-parietal network based on goals

Abstract

The relationship between top-down enhancement and suppression of sensory cortical activity and large-scale neural networks remains unclear. Functional connectivity analysis of human functional magnetic resonance imaging data revealed that visual cortical areas that selectively process relevant information are functionally connected with the frontal-parietal network, whereas those that process irrelevant information are simultaneously coupled with the default network. This indicates that sensory cortical regions are differentially and dynamically coupled with distinct networks on the basis of task goals.

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Figure 1: Experimental procedure.
Figure 2: Network connectivity.

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Acknowledgements

We would like to thank A. Rutman, M. Ruben, J.A. Anguera, E. Morsella and T. Zanto for their assistance. This work was supported by the grants from the US National Institutes of Health, including 5R01AG030395 (A.G.), and Larry L. Hillblom Center for the Biology of Aging Graduate Fellowship (J.Z.C.).

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Authors and Affiliations

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Contributions

J.Z.C. and A.G. designed the experiment. J.Z.C. collected and analyzed data. J.Z.C. and A.G. wrote the paper.

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Correspondence to Adam Gazzaley.

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The authors declare no competing financial interests.

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Supplementary Text and Figures

Supplementary Figures 1–8, Supplementary Tables 1–3, Supplementary Discussion, Supplementary Methods and Supplementary Results (PDF 2498 kb)

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Chadick, J., Gazzaley, A. Differential coupling of visual cortex with default or frontal-parietal network based on goals. Nat Neurosci 14, 830–832 (2011). https://doi.org/10.1038/nn.2823

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