A new study challenges the idea that the ventromedial prefrontal cortex inhibits drug relapse, by selectively inactivating a subpopulation of neurons in this brain area and showing attenuation of context-induced reinstatement of heroin seeking.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
McLellan, A.T., Lewis, D.C., O'Brien, C.P. & Kleber, H.D. J. Am. Med. Assoc. 284, 1689–1695 (2000).
Bossert, J.M. et al. Nat. Neurosci. 14, 420–422 (2011).
Jentsch, J.D. & Taylor, J.R. Psychopharmacology (Berl.) 146, 373–390 (1999).
Goldstein, R.Z. & Volkow, N.D. Am. J. Psychiatry 159, 1642–1652 (2002).
Peters, J., Kalivas, P.W. & Quirk, G.J. Learn. Mem. 16, 279–288 (2009).
Koya, E. et al. Nat. Neurosci. 12, 1069–1073 (2009).
Gabbott, P.L., Warner, T.A., Jays, P.R., Salway, P. & Busby, S.J. J. Comp. Neurol. 492, 145–177 (2005).
Damasio, A.R. Descartes' Error: Emotion, Reason, and the Human Brain (Putnam, New York, 1994).
Bechara, A., Damasio, A.R., Damasio, H. & Anderson, S.W. Cognition 50, 7–15 (1994).
Clark, L. et al. Brain 131, 1311–1322 (2008).
Heinz, A. et al. Alcohol Alcohol. 38, 35–39 (2003).
Stinus, L., Caille, S. & Koob, G.F. Psychopharmacology (Berl.) 149, 115–120 (2000).
O'Brien, C.P., Testa, J., O'Brien, T.J., Brady, J.P. & Wells, B. Science 195, 1000–1002 (1977).
Kenny, P.J., Chen, S.A., Kitamura, O., Markou, A. & Koob, G.F. J. Neurosci. 26, 5894–5900 (2006).
Greenwell, T.N. et al. Addict. Biol. 14, 130–143 (2009).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
George, O., Koob, G. Craving, context and the cortex. Nat Neurosci 14, 409–410 (2011). https://doi.org/10.1038/nn.2787
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2787