Histone deacetylases (HDACs) are major epigenetic regulators. We show that HDAC1 and HDAC2 functions are critical for myelination of the peripheral nervous system. Using mouse genetics, we have ablated Hdac1 and Hdac2 specifically in Schwann cells, resulting in massive Schwann cell loss and virtual absence of myelin in mutant sciatic nerves. Expression of Sox10 and Krox20, the main transcriptional regulators of Schwann cell myelination, was greatly reduced. We demonstrate that in Schwann cells, HDAC1 and HDAC2 exert specific primary functions: HDAC2 activates the transcriptional program of myelination in synergy with Sox10, whereas HDAC1 controls Schwann cell survival by regulating the levels of active β-catenin.
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We thank M. Wegner (Universtät Erlangen-Nürnberg), E. Seto (Moffitt Cancer Center), S. Schreiber (Harvard University), Z. Werb and B. Welm (University of Utah), J. Crabtree (Stanford University), T. Reya (Duke University Medical Center), W.J. Pavan (US National Institutes of Health), A. McCallion and M. Prasad (Johns Hopkins University School of Medicine) and D.R. Colman (McGill University) for providing constructs and antibodies, T. Meier, W. Seufert and N. Mantei for critically reading the manuscript and the Functional Genomic Center Zurich for gene array analyses. These studies were supported by two Swiss National Science Foundation (SNSF) grants, a Marie-Heim Vögtlin subsidy (PMPDP3_122738/1) to C. Jacob, and another SNSF grant to U. Suter, and by a grant from the Swiss National Center for Competence in Research (NCCR) Neural Plasticity and Repair to U. Suter. The work in the laboratory of P. Matthias was supported by the Novartis Research Foundation.
The authors declare no competing financial interests.
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Jacob, C., Christen, C., Pereira, J. et al. HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat Neurosci 14, 429–436 (2011) doi:10.1038/nn.2762
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