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Anatomically distinct dopamine release during anticipation and experience of peak emotion to music


Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of [11C]raclopride positron emission tomography scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening. To examine the time course of dopamine release, we used functional magnetic resonance imaging with the same stimuli and listeners, and found a functional dissociation: the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak emotional responses to music. These results indicate that intense pleasure in response to music can lead to dopamine release in the striatal system. Notably, the anticipation of an abstract reward can result in dopamine release in an anatomical pathway distinct from that associated with the peak pleasure itself. Our results help to explain why music is of such high value across all human societies.

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Figure 1: Positive correlation between emotional arousal and intensity of chills during PET scanning.
Figure 2: Evidence for dopamine release during pleasurable music listening.
Figure 3: Combined fMRI and PET results reveal temporal distinctions in regions showing dopamine release.
Figure 4: Brain and behavior relationships involving temporal components of pleasure during music listening.
Figure 5: Brain and behavior relationships involving parametric increases in pleasure during music listening.


  1. 1

    Egerton, A. et al. The dopaminergic basis of human behaviors: a review of molecular imaging studies. Neurosci. Biobehav. Rev. 33, 1109–1132 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Dube, L. & Lebel, J. The content and structure of laypeople's concept of pleasure. Cogn. Emot. 17, 263–295 (2003).

    Article  Google Scholar 

  3. 3

    Sloboda, J. & Juslin, P.N. Psychological perspectives on music and emotion. in Music and Emotion: Theory and Research (ed. Sloboda, J.) 71–104 (Oxford University Press, Oxford, 2001).

  4. 4

    Krumhansl, C.L. An exploratory study of musical emotions and psychophysiology. Can. J. Exp. Psychol. 51, 336–353 (1997).

    CAS  Article  Google Scholar 

  5. 5

    Blood, A.J. & Zatorre, R.J. Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proc. Natl. Acad. Sci. USA 98, 11818–11823 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Menon, V. & Levitin, D.J. The rewards of music listening: response and physiological connectivity of the mesolimbic system. Neuroimage 28, 175–184 (2005).

    CAS  Article  Google Scholar 

  7. 7

    Koelsch, S., Fritz, T., Cramon, D., Muller, K. & Friederici, A.D. Investigating emotion with music: an fMRI study. Hum. Brain Mapp. 27, 239–250 (2006).

    Article  Google Scholar 

  8. 8

    Mitterschiffthaler, M.T., Fu, C.H.Y., Dalton, J., Andrew, C.M. & Williams, S. A functional MRI study of happy and sad affective states induced by classical music. Hum. Brain Mapp. 28, 1150–1162 (2007).

    Article  Google Scholar 

  9. 9

    Knutson, B. & Gibbs, S.E. Linking nucelus accumbens dopamine and blood oxygenation. Psychopharmacology (Berl.) 191, 813–822 (2007).

    CAS  Article  Google Scholar 

  10. 10

    Laruelle, M. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J. Cereb. Blood Flow Metab. 20, 423–451 (2000).

    CAS  Article  Google Scholar 

  11. 11

    Huron, D. & Hellmuth Margulis, E. Musical expectancy and thrills. in Music and Emotion (eds. Juslin, P.N. & Sloboda, J.) (Oxford University Press, New York, 2009).

  12. 12

    Grewe, O., Nagel, F., Kopiez, R. & Altenmuller, E. Emotions over time: synchronicity and development of subjective, physiological, and facial affective reactions to music. Emotion 7, 774–788 (2007).

    Article  Google Scholar 

  13. 13

    Panksepp, J. The emotional source of “chills” induced by music. Music Percept. 13, 171–207 (1995).

    Article  Google Scholar 

  14. 14

    Sloboda, J. Music structure and emotional response: some empirical findings. Psychol. Music 19, 110–120 (1991).

    Article  Google Scholar 

  15. 15

    Salimpoor, V.N., Benovoy, M., Longo, G., Cooperstock, J.R. & Zatorre, R.J. The rewarding aspects of music listening are related to degree of emotional arousal. PLoS ONE 4, e7487 (2009).

    Article  Google Scholar 

  16. 16

    O'Doherty, J.P., Deichmann, R., Critchley, H.D. & Dolan, R. Neural responses during anticipation of a primary taste reward. Neuron 33, 815–826 (2002).

    CAS  Article  Google Scholar 

  17. 17

    Schultz, W., Dayan, P. & Montague, P.R. A neural substrate of prediction and reward. Science 275, 1593–1599 (1997).

    CAS  Article  Google Scholar 

  18. 18

    Wise, R.A. Dopamine, learning and motivation. Nat. Rev. Neurosci. 5, 483–494 (2004).

    CAS  Article  Google Scholar 

  19. 19

    Huron, D. Sweet Anticipation: Music and the Psychology of Expectation (MIT Press, Cambridge, Massachusetts, 2006).

  20. 20

    Meyer, L.B. Emotion and Meaning in Music. (University of Chicago Press, Chicago, 1956).

    Google Scholar 

  21. 21

    Schott, B.H. et al. Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. J. Neurosci. 28, 14311–14319 (2008).

    CAS  Article  Google Scholar 

  22. 22

    Kriegeskorte, N., Simmons, W.K., Bellgowan, P.S. & Baker, C.I. Circular analysis in systems neuroscience: the dangers of double dipping. Nat. Neurosci. 12, 535–540 (2009).

    CAS  Article  Google Scholar 

  23. 23

    Volkow, N.D. et al. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386, 827–830 (1997).

    CAS  Article  Google Scholar 

  24. 24

    Haber, S. & Knutson, B. The reward circuit: linking primate anatomy and human imaging. Neuropharmacology 35, 4–26 (2010).

    Google Scholar 

  25. 25

    Haber, S.N., Kim, K.S., Mailly, P. & Calzavara, R. Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning. J. Neurosci. 26, 8368–8376 (2006).

    CAS  Article  Google Scholar 

  26. 26

    Valentin, V.V. & O'Doherty, J.P. Overlapping prediction errors in dorsal striatum during instrumental learning with juice and money reward in the human brain. J. Neurophysiol. 102, 3384–3391 (2009).

    Article  Google Scholar 

  27. 27

    Small, D.M., Jones-Gotman, M. & Dagher, A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19, 1709–1715 (2003).

    Article  Google Scholar 

  28. 28

    Boileau, I. et al. Modeling sensiitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men. Arch. Gen. Psychiatry 63, 1386–1395 (2006).

    CAS  Article  Google Scholar 

  29. 29

    Barrett, S.P., Boileau, I., Okker, J., Pihl, R.O. & Dagher, A. The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse 54, 65–71 (2004).

    CAS  Article  Google Scholar 

  30. 30

    Leyton, M. et al. Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27, 1027–1035 (2002).

    CAS  Article  Google Scholar 

  31. 31

    Boileau, I. et al. Alcohol promotes dopamine release in the human nuclus accumbens. Synapse 49, 226–231 (2003).

    CAS  Article  Google Scholar 

  32. 32

    Everitt, B.J. & Robbins, T. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481–1489 (2005).

    CAS  Article  Google Scholar 

  33. 33

    Rickard, N.S. Intense emotional responses to music: a test of the physiological arousal hypothesis. Psychol. Music 32, 371–388 (2004).

    Article  Google Scholar 

  34. 34

    Grewe, O., Kopiez, R. & Altenmuller, E. Chills as an indicator of individual emotional peaks. Ann. NY Acad. Sci. 1169, 351–354 (2009).

    Article  Google Scholar 

  35. 35

    Zald, D.H. et al. Dopamine transmission in the human striatum during monetary reward tasks. J. Neurosci. 24, 4105–4112 (2004).

    CAS  Article  Google Scholar 

  36. 36

    Koepp, M.J. et al. Evidence for striatal dopamine release during a video game. Nature 393, 266–268 (1998).

    CAS  Article  Google Scholar 

  37. 37

    Zald, D.H. & Zatorre, R.J. On music and reward. in The Neurobiology of Sensation and Reward (ed. Gottfried, J.A.) (CRC Press, 2011).

  38. 38

    Costes, N. et al. Motion correction of multi-frame PET data in neuroreceptor mapping: simulation based validation. Neuroimage 47, 1496–1505 (2009).

    Article  Google Scholar 

  39. 39

    Collins, D.L., Peters, T.M. & Evans, A.C. Automatic 3D intersubject registration of MR volumetric data in standardized Talirach space. J. Comput. Assist. Tomogr. 18, 192–205 (1994).

    CAS  Article  Google Scholar 

  40. 40

    Gunn, R.N., Lammertsma, A.A., Hume, S.P. & Cunningham, V.J. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6, 279–287 (1997).

    CAS  Article  Google Scholar 

  41. 41

    Lammertsma, A.A. & Hume, S.P. Simplified reference tissue model for PET receptor studies. Neuroimage 4, 153–158 (1996).

    CAS  Article  Google Scholar 

  42. 42

    Litton, J.E., Hall, H. & Pauli, S. Saturation analysis in PET-analysis of errors due to non-perfect reference regions. J. Cereb. Blood Flow Metab. 14, 358–361 (1994).

    CAS  Article  Google Scholar 

  43. 43

    Collins, D.L. & Evans, A.C. ANIMAL: Validation and application of nonlinear registration-based segmentation. Intern. J. Pattern Recognit. Artif. Intell. 11, 1271–1294 (1997).

    Article  Google Scholar 

  44. 44

    Zijdenbos, A., Forghani, R. & Evans, A.C. Automatic quantification of MS lesions in 3D MRI Brain data sets: validation of INSECT. in Medical Image Computing and Computer-Assisted Intervention (eds. Wells, W.M., Colchester, A. & Delp, S.) 439–448 (Springer-Verlag, Cambridge, Massachusetts, 1998).

  45. 45

    Aston, J.A. et al. A statistical method for the analysis of positron emission tomography neuroreceptor ligand data. Neuroimage 12, 245–256 (2000).

    CAS  Article  Google Scholar 

  46. 46

    Endres, C.J. et al. Kinetic modeling of [11C]raclopride: combined PET microdialysis studies. J. Cereb. Blood Flow Metab. 17, 932–942 (1997).

    CAS  Article  Google Scholar 

  47. 47

    Worsley, K.J. et al. A unified statistical approach for determining significant signals in images of cerebral activation. Hum. Brain Mapp. 4, 58–73 (1996).

    CAS  Article  Google Scholar 

  48. 48

    Worsley, K.J. et al. A general statistical analysis for fMRI data. Neuroimage 15, 1–15 (2002).

    CAS  Article  Google Scholar 

  49. 49

    Slifstein, M. et al. Striatal and extrastriatal dopamine release measured with PET and [(18)F]fallypride. Synapse 64, 350–362 (2010).

    CAS  Article  Google Scholar 

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We thank the staff of the Montreal Neurological Institute PET and MR Units and the staff of the Centre for Interdisciplinary Research in Music Media and Technology for help with data acquisition, M. Ferreira and M. Bouffard for their assistance with data analysis, and G. Longo for assistance with stimulus preparation. This research was supported by funding from the Canadian Institutes of Health Research to R.J.Z., a Natural Science and Engineering Research Council stipend to V.N.S., a Jeanne Timmins Costello award to V.N.S. and Centre for Interdisciplinary Research in Music Media and Technology awards to V.N.S. and M.B.

Author information




V.N.S., R.J.Z. and A.D. designed the study. V.N.S. and M.B. performed all experiments. V.N.S., M.B. and K.L. analyzed the data. V.N.S. and R.J.Z. wrote the manuscript.

Corresponding authors

Correspondence to Valorie N Salimpoor or Robert J Zatorre.

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The authors declare no competing financial interests.

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Salimpoor, V., Benovoy, M., Larcher, K. et al. Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat Neurosci 14, 257–262 (2011).

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