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Perinatal photoperiod imprints the circadian clock

Nature Neuroscience volume 14, pages 2527 (2011) | Download Citation

Abstract

Using real-time gene expression imaging and behavioral analysis, we found that the perinatal photoperiod has lasting effects on the circadian rhythms expressed by clock neurons as well as on mouse behavior, and sets the responsiveness of the biological clock to subsequent changes in photoperiod. These developmental gene × environment interactions tune circadian clock responses to subsequent seasonal photoperiods and may contribute to the influence of season on neurobehavioral disorders in humans.

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References

  1. 1.

    et al. Pediatr. Res. 60, 304–308 (2006).

  2. 2.

    et al. J. Comp. Neurol. 191, 1–51 (1980).

  3. 3.

    & Nature 456, 195–201 (2008).

  4. 4.

    & J. Neurophysiol. 26, 978–993 (1963).

  5. 5.

    & J. Neurophysiol. 26, 1003–1017 (1963).

  6. 6.

    & Curr. Biol. 18, R784–R794 (2008).

  7. 7.

    et al. J. Neurosci. 29, 1670–1676 (2009).

  8. 8.

    et al. Proc. Natl. Acad. Sci. USA 104, 7664–7669 (2007).

  9. 9.

    et al. Curr. Biol. 17, 468–473 (2007).

  10. 10.

    et al. J. Biol. Rhythms 23, 140–149 (2008).

  11. 11.

    et al. Neuron 58, 78–88 (2008).

  12. 12.

    et al. J. Neurosci. Res. 64, 612–616 (2001).

  13. 13.

    & J. Comp. Physiol. A 165, 41–49 (1989).

  14. 14.

    & Behav. Neurosci. 120, 125–134 (2006).

  15. 15.

    et al. Arch. Gen. Psychiatry 58, 1108–1114 (2001).

Download references

Acknowledgements

The authors would like to thank J.Y. Cohen for kindly providing custom software programming. This work was supported by US National Institutes of Health grants P50 MH078028 (D.G.M.), T32 MH64913 and F31 MH080547 (C.M.C.).

Author information

Author notes

    • Karen L Gamble

    Present address: Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Affiliations

  1. Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee, USA.

    • Christopher M Ciarleglio
    •  & Douglas G McMahon
  2. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.

    • Christopher M Ciarleglio
    • , John C Axley
    • , Benjamin R Strauss
    • , Karen L Gamble
    •  & Douglas G McMahon

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Contributions

C.M.C. and D.G.M. designed the experiments. C.M.C., J.C.A. and B.R.S. performed the experiments and compiled the results. C.M.C. and K.L.G. performed statistical analyses. C.M.C. and D.G.M. wrote the paper.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Douglas G McMahon.

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    Supplementary Text and Figures

    Supplementary Figures 1 and 2, Supplementary Tables 1–3, Supplementary Methods and Supplementary Results

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DOI

https://doi.org/10.1038/nn.2699

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