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Plasticity and specificity of the circadian epigenome

Nature Neuroscience volume 13, pages 1324–1329 (2010)Cite this article

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Abstract

Circadian clocks control a variety of neuronal, behavioral and physiological responses, via transcriptional regulation of an appreciable portion of the genome. We describe the complex communication network between the brain-specific central clock and the tissue-specific peripheral clocks that serve to synchronize the organism to both external and internal demands. In addition, we discuss and speculate on how epigenetic processes are involved in creating transcriptional environments that are permissive to tissue-specific gene expression programs, which work in concert with the circadian machinery. Accumulating data show that chromatin remodeling events may be critical for providing specificity and plasticity in circadian regulation, and metabolic cues may be involved in directing such epigenetic events. A detailed understanding of the communication cues between the central and peripheral clocks is crucial for a more complete understanding of the circadian system and the several levels of control that are implicated in maintaining biological timekeeping.

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Figure 1: The circadian CLOCK network.
Figure 2: What underlies the different genomic responses of central versus peripheral clocks? Approximately 10% of transcripts in a given tissue show circadian expression.
Figure 3: Chromatin remodeling and the circadian clock.

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Acknowledgements

We thank all members of our laboratory for discussions and support. Work in the laboratory is supported by the US National Institute of Health and the INSERM (Institut National de la Santé et la Recherche Médicale), France.

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  1. Department of Pharmacology, U904 INSERM 'Epigenetics and Neuronal Plasticity', School of Medicine, University of California, Irvine, California, USA

    Selma Masri & Paolo Sassone-Corsi

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Correspondence to Paolo Sassone-Corsi.

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Masri, S., Sassone-Corsi, P. Plasticity and specificity of the circadian epigenome. Nat Neurosci 13, 1324–1329 (2010). https://doi.org/10.1038/nn.2668

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