Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior.
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We thank J. Lerma, A. Nieto, M.L. Ceci, A. Blanchart and J. García-Marqués for helpful comments; P. Bovolenta and C. Sánchez-Camacho for their kind gift of the pCAG plasmid; F. Vaccarino and G. Corte for the generous gift of antibodies to Otp and Foxg1; L. Menéndez de la Prida for providing the GAD-GFP transgenic mice; A. Kastanauskaite and L. María Suarez for their help with the intracellular injections of Lucifer Yellow and M. Sefton for editorial assistance. This work was supported by grants from the Ministerio de Ciencia e Innovación (BFU2007-60351/BFI), the OLFACTOSENSE Consortium of the Comunidad Autónoma de Madrid (P-SEM-0255-2006) and the Castilla-La Mancha Health Research Foundation (FISCAM PI2007-66) to J.A.DC., and the FP6 for the EUTRACC Integrate Project (LSHG-CT-2007-037445), the 'Stem Cell Project' of Fondazione Roma and the Italian Association for Cancer Research to A.S. Funding for M.P. was provided by Fundación Centro de Investigaciones de Enfermedades Neurológicas (PI006-08).
The authors declare no competing financial interests.
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García-Moreno, F., Pedraza, M., Di Giovannantonio, L. et al. A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat Neurosci 13, 680–689 (2010). https://doi.org/10.1038/nn.2556
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