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Selective suppression of hippocampal ripples impairs spatial memory

Nature Neuroscience volume 12, pages 1222–1223 (2009)Cite this article

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Abstract

Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

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Figure 1: Ventral hippocampal commissural stimulation interrupts SPW-Rs and hippocampal cell discharges without changing global sleep architecture.
Figure 2: Suppression of SPW-Rs interferes with memory consolidation.

Change history

  • 20 September 2009

    In the version of this supplementary file originally posted online, part of Supplementary Figure 3 was missing. The error has been corrected in this file as of 20 September 2009. In addition, Gabrielle Girardeau was incorrectly listed as a corresponding author in the HTML version that was originally posted online. The correct corresponding author is György Buzsáki. The error has been corrected in the HTML version of the article.

References

  1. Squire, L.R. & Bayley, P.J. Curr. Opin. Neurobiol. 17, 185–196 (2007).

    Article  CAS  Google Scholar 

  2. Maviel, T., Durkin, T.P., Menzaghi, F. & Bontempi, B. Science 305, 96–99 (2004).

    Article  CAS  Google Scholar 

  3. Buzsáki, G. Neuroscience 31, 551–570 (1989).

    Article  Google Scholar 

  4. Marshall, L., Helgadóttir, H., Mölle, M. & Born, J. Nature 444, 610–613 (2006).

    Article  CAS  Google Scholar 

  5. Kudrimoti, H.S., Barnes, C.A. & McNaughton, B.L. J. Neurosci. 19, 4090–4101 (1999).

    Article  CAS  Google Scholar 

  6. Wilson, M.A. & McNaughton, B.L. Science 265, 676–679 (1994).

    Article  CAS  Google Scholar 

  7. Chrobak, J.J. & Buzsáki, G. J. Neurosci. 16, 3056–3066 (1996).

    Article  CAS  Google Scholar 

  8. Battaglia, F.P., Sutherland, G.R. & McNaughton, B.L. Learn. Mem. 11, 697–704 (2004).

    Article  Google Scholar 

  9. Siapas, A.G. & Wilson, M.A. Neuron 21, 1123–1128 (1998).

    Article  CAS  Google Scholar 

  10. Sirota, A., Csicsvari, J., Buhl, D. & Buzsáki, G. Proc. Natl. Acad. Sci. USA 100, 2065–2069 (2003).

    Article  CAS  Google Scholar 

  11. Jarrard, L.E. Behav. Brain Res. 71, 1–10 (1995).

    Article  CAS  Google Scholar 

  12. Zugaro, M.B., Monconduit, L. & Buzsáki, G. Nat. Neurosci. 8, 67–71 (2005).

    Article  CAS  Google Scholar 

  13. O'Keefe, J. & Nadel, L. The Hippocampus as a Cognitive Map (Oxford University Press, Oxford, 1978).

    Google Scholar 

  14. Eschenko, O., Ramadan, W., Mölle, M., Born, J. & Sara, S.J. Learn. Mem. 15, 222–228 (2008).

    Article  Google Scholar 

  15. Peyrache, A., Khamassi, M., Benchenane, K., Wiener, S.I. & Battaglia, F. Nat. Neurosci. 12, 919–926 (2009).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank S. Sara, A. Larrieu, L. Hazan, A. Fruchart, P. Ruther, S. Kisban, S. Herwik, S. Doutremer, M.-A. Thomas, Y. Dupraz, M. Ehrette and S. Rateau for advice and technical support. This work was supported by the International Human Frontiers Science Program Organization (CDA0061/2007-C), the US National Institutes of Health (NS34994), European Projects NeuroProbes (IST-027017) and Integrating Cognition, Emotion and Autonomy (FP6-IST 027819), and a Collège de France Visiting Professor Fellowship.

Author information

Author notes

  1. Gabrielle Girardeau and Karim Benchenane: These authors contributed equally to this work.

Authors and Affiliations

  1. Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France

    Gabrielle Girardeau, Karim Benchenane, Sidney I Wiener & Michaël B Zugaro

  2. Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA

    György Buzsáki

Authors
  1. Gabrielle Girardeau
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  2. Karim Benchenane
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  3. Sidney I Wiener
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  4. György Buzsáki
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  5. Michaël B Zugaro
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Contributions

G.B. and M.B.Z. designed the study. G.G. carried out the majority of the experiments, K.B. and M.B.Z. carried out the remaining experiments. M.B.Z., G.G. and K.B. analyzed the data. All of the authors contributed to writing the manuscript.

Corresponding authors

Correspondence to György Buzsáki or Michaël B Zugaro.

Supplementary information

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Supplementary Figures 1–6 and Supplementary Methods (PDF 3147 kb)

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Girardeau, G., Benchenane, K., Wiener, S. et al. Selective suppression of hippocampal ripples impairs spatial memory. Nat Neurosci 12, 1222–1223 (2009). https://doi.org/10.1038/nn.2384

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