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L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala


The molecular mechanisms underlying the expression of postsynaptic long-term potentiation (LTP) at glutamatergic synapses are well understood. However, little is known about those that mediate the expression of presynaptic LTP. We found that presynaptic LTP at cortical inputs to the mouse lateral amygdala was blocked and reversed by L-type voltage-dependent Ca2+ channel (L-VDCC) blockers. Thus, a persistent increase in L-VDCC–mediated glutamate release underlies the expression of presynaptic LTP in the amygdala.

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Figure 1: Differential role of distinct VDCC subtypes in synaptic transmission and plasticity.
Figure 2: L-VDCC mediate expression of presynaptic LTP.

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  1. Malinow, R. & Malenka, R.C. Annu. Rev. Neurosci. 25, 103–126 (2002).

    Article  CAS  Google Scholar 

  2. Nicoll, R.A. & Schmitz, D. Nat. Rev. Neurosci. 6, 863–876 (2005).

    Article  CAS  Google Scholar 

  3. Catterall, W.A. Annu. Rev. Cell Dev. Biol. 16, 521–555 (2000).

    Article  CAS  Google Scholar 

  4. Catterall, W.A. & Few, A.P. Neuron 59, 882–901 (2008).

    Article  CAS  Google Scholar 

  5. Mato, S. et al. Neuropharmacology 54, 87–94 (2008).

    Article  CAS  Google Scholar 

  6. Pelkey, K.A., Topolnik, L., Lacaille, J.C. & McBain, C.J. Neuron 52, 497–510 (2006).

    Article  CAS  Google Scholar 

  7. LeDoux, J.E. Annu. Rev. Neurosci. 23, 155–184 (2000).

    Article  CAS  Google Scholar 

  8. Humeau, Y., Shaban, H., Bissière, S. & Lüthi, A. Nature 426, 841–845 (2003).

    Article  CAS  Google Scholar 

  9. Fourcaudot, E. et al. Proc. Natl. Acad. Sci. USA 105, 15130–15135 (2008).

    Article  CAS  Google Scholar 

  10. Castillo, P.E., Weisskopf, M.G. & Nicoll, R.A. Neuron 12, 261–269 (1994).

    Article  CAS  Google Scholar 

  11. Fisher, R.E., Gray, R. & Johnston, D. J. Neurophysiol. 64, 91–104 (1990).

    Article  CAS  Google Scholar 

  12. Coppola, T. et al. J. Biol. Chem. 276, 32756–32762 (2001).

    Article  CAS  Google Scholar 

  13. Kiyonaka, S. et al. Nat. Neurosci. 10, 691–701 (2007).

    Article  CAS  Google Scholar 

  14. Bauer, E.P., Schafe, G.E. & LeDoux, J.E. J. Neurosci. 22, 5239–5249 (2002).

    Article  CAS  Google Scholar 

  15. Shinnick-Gallagher, P., McKernan, M.G., Xie, J. & Zinebi, F. Ann. NY Acad. Sci. 985, 135–149 (2003).

    Article  CAS  Google Scholar 

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We thank J. Letzkus and all members of the Lüthi laboratory for helpful discussions and comments on the manuscript. This study was supported by the Agence Nationale pour la Recherche, the European Neuroscience Institutes Network, the Eucor Learning and Teaching Mobility Program, the Swiss National Science Foundation, the Austrian Science Fund and the Novartis Research Foundation.

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E.F., F.G, G.C., B.P., Y.H. and A.L. designed the study. E.F., F.G., G.C. and Y.H. carried out the experiments. E.F., F.G., G.C., B.P., Y.H. and A.L. analyzed the data. E.F., G.C., B.P., Y.H. and A.L. wrote the manuscript.

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Correspondence to Andreas Lüthi.

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Fourcaudot, E., Gambino, F., Casassus, G. et al. L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala. Nat Neurosci 12, 1093–1095 (2009).

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