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Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb

Nature Neuroscience volume 12, pages 731–733 (2009)Cite this article

Abstract

Using two photon–guided focal stimulation, we found spike timing–dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originated, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell excitatory postsynaptic potentials and mitral cell inhibition were also potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a mechanism for encoding information by modulating bulbar inhibition.

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Figure 1: Spike timing–dependent plasticity of proximal excitatory inputs to granule cells.
Figure 2: LTP evoked by TBS.

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Acknowledgements

We thank T. Pressler and P. Larimer for helpful discussions and constructive comments on this manuscript. This work was supported by US National Institutes of Health grant R01-DC04285 to B.W.S.

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Authors and Affiliations

  1. Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA

    Yuan Gao & Ben W Strowbridge

Authors
  1. Yuan Gao
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  2. Ben W Strowbridge
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Contributions

Y.G. and B.W.S. designed the experiments, analyzed the data and wrote the manuscript. Y.G. conducted the experiments.

Corresponding author

Correspondence to Ben W Strowbridge.

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Gao, Y., Strowbridge, B. Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb. Nat Neurosci 12, 731–733 (2009). https://doi.org/10.1038/nn.2319

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