Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Abstract

To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis–dependent olfactory learning.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Maturation of excitatory input onto newborn granule cells.
Figure 2: Newborn granule cells show LTP at glutamatergic synapses.
Figure 3: Calcium-dependent postsynaptic induction and presynaptic maintenance of LTP.

References

  1. Altman, J. J. Comp. Neurol. 137, 433–457 (1969).

    Article  CAS  Google Scholar 

  2. Lledo, P.-M., Alonso, M. & Grubb, M.S. Nat. Rev. Neurosci. 7, 179–193 (2006).

    Article  CAS  Google Scholar 

  3. Schmidt-Hieber, C., Jonas, P. & Bischofberger, J. Nature 429, 184–187 (2004).

    Article  CAS  Google Scholar 

  4. Ge, S., Yang, C.H., Hsu, K.S., Ming, G.L. & Song, H. Neuron 54, 559–566 (2007).

    Article  CAS  Google Scholar 

  5. Shepherd, G.M., Wei, R.C. & Greer, C.A. The Synaptic Organization of the Brain, 5th edn. (ed. Shepherd, G.M.) (Oxford University Press, Oxford, 2004).

    Book  Google Scholar 

  6. Patneau, D.K. & Stripling, J.S. Brain Res. 585, 219–228 (1992).

    Article  CAS  Google Scholar 

  7. Kitazawa, H., Yagi, T., Miyakawa, T., Niki, H. & Kawai, N. J. Neurophysiol. 79, 137–142 (1998).

    Article  CAS  Google Scholar 

  8. Balu, R., Pressler, R.T. & Strowbridge, B.W. J. Neurosci. 27, 5621–5632 (2007).

    Article  CAS  Google Scholar 

  9. Faber, D.S. & Korn, H. Biophys. J. 60, 1288–1294 (1991).

    Article  CAS  Google Scholar 

  10. Kandel, E.R. Science 294, 1030–1038 (2001).

    Article  CAS  Google Scholar 

  11. Kullmann, D.M. & Lamsa, K.P. Nat. Rev. Neurosci. 8, 687–699 (2007).

    Article  CAS  Google Scholar 

  12. Davis, B.J. & Macrides, F. J. Comp. Neurol. 203, 475–493 (1981).

    Article  CAS  Google Scholar 

  13. Rinberg, D., Koulakov, A. & Gelperin, A. J. Neurosci. 26, 8857–8865 (2006).

    Article  CAS  Google Scholar 

  14. Magavi, S.S., Mitchell, B.D., Szentirmai, O., Carter, B.S. & Macklis, J.D. J. Neurosci. 25, 10729–10739 (2005).

    Article  CAS  Google Scholar 

  15. Mouret, A. et al. J. Neurosci. 28, 11511–11516 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank M. Alonso for technical help with viral injections and M. Grubb for insightful comments on the manuscript. A.N. was supported by the Pasteur Institute; and P.-M.L., by the Fondation pour la Recherche Médicale “Equipe FRM,” Agence Nationale de la Recherche (ANR-05-Neur-028-01), Ecole des Neurosciences de Paris and the Groupe Ionis. The Lledo laboratory is a member of the Network of European Neuroscience Institutes (LSHM-CT-2005-019063).

Author information

Authors and Affiliations

Authors

Contributions

A.N. carried out the electrophysiology and immunochemistry, C.B. contributed to the electrophysiology and performed virus injections, H.K. contributed to analysis, and K.M. generated the lentiviral vectors. A.N. and P.-M.L. designed all of the experiments and wrote the manuscript.

Corresponding author

Correspondence to Pierre-Marie Lledo.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–6 and Supplementary Methods (PDF 510 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nissant, A., Bardy, C., Katagiri, H. et al. Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nat Neurosci 12, 728–730 (2009). https://doi.org/10.1038/nn.2298

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.2298

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing