Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Abstract

To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis–dependent olfactory learning.

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Figure 1: Maturation of excitatory input onto newborn granule cells.
Figure 2: Newborn granule cells show LTP at glutamatergic synapses.
Figure 3: Calcium-dependent postsynaptic induction and presynaptic maintenance of LTP.

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Acknowledgements

We thank M. Alonso for technical help with viral injections and M. Grubb for insightful comments on the manuscript. A.N. was supported by the Pasteur Institute; and P.-M.L., by the Fondation pour la Recherche Médicale “Equipe FRM,” Agence Nationale de la Recherche (ANR-05-Neur-028-01), Ecole des Neurosciences de Paris and the Groupe Ionis. The Lledo laboratory is a member of the Network of European Neuroscience Institutes (LSHM-CT-2005-019063).

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Contributions

A.N. carried out the electrophysiology and immunochemistry, C.B. contributed to the electrophysiology and performed virus injections, H.K. contributed to analysis, and K.M. generated the lentiviral vectors. A.N. and P.-M.L. designed all of the experiments and wrote the manuscript.

Corresponding author

Correspondence to Pierre-Marie Lledo.

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Supplementary Figures 1–6 and Supplementary Methods (PDF 510 kb)

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Nissant, A., Bardy, C., Katagiri, H. et al. Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nat Neurosci 12, 728–730 (2009). https://doi.org/10.1038/nn.2298

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