Adult neurogenesis promotes synaptic plasticity in the olfactory bulb


To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis–dependent olfactory learning.

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Figure 1: Maturation of excitatory input onto newborn granule cells.
Figure 2: Newborn granule cells show LTP at glutamatergic synapses.
Figure 3: Calcium-dependent postsynaptic induction and presynaptic maintenance of LTP.


  1. 1

    Altman, J. J. Comp. Neurol. 137, 433–457 (1969).

    CAS  Article  Google Scholar 

  2. 2

    Lledo, P.-M., Alonso, M. & Grubb, M.S. Nat. Rev. Neurosci. 7, 179–193 (2006).

    CAS  Article  Google Scholar 

  3. 3

    Schmidt-Hieber, C., Jonas, P. & Bischofberger, J. Nature 429, 184–187 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Ge, S., Yang, C.H., Hsu, K.S., Ming, G.L. & Song, H. Neuron 54, 559–566 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Shepherd, G.M., Wei, R.C. & Greer, C.A. The Synaptic Organization of the Brain, 5th edn. (ed. Shepherd, G.M.) (Oxford University Press, Oxford, 2004).

    Google Scholar 

  6. 6

    Patneau, D.K. & Stripling, J.S. Brain Res. 585, 219–228 (1992).

    CAS  Article  Google Scholar 

  7. 7

    Kitazawa, H., Yagi, T., Miyakawa, T., Niki, H. & Kawai, N. J. Neurophysiol. 79, 137–142 (1998).

    CAS  Article  Google Scholar 

  8. 8

    Balu, R., Pressler, R.T. & Strowbridge, B.W. J. Neurosci. 27, 5621–5632 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Faber, D.S. & Korn, H. Biophys. J. 60, 1288–1294 (1991).

    CAS  Article  Google Scholar 

  10. 10

    Kandel, E.R. Science 294, 1030–1038 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Kullmann, D.M. & Lamsa, K.P. Nat. Rev. Neurosci. 8, 687–699 (2007).

    CAS  Article  Google Scholar 

  12. 12

    Davis, B.J. & Macrides, F. J. Comp. Neurol. 203, 475–493 (1981).

    CAS  Article  Google Scholar 

  13. 13

    Rinberg, D., Koulakov, A. & Gelperin, A. J. Neurosci. 26, 8857–8865 (2006).

    CAS  Article  Google Scholar 

  14. 14

    Magavi, S.S., Mitchell, B.D., Szentirmai, O., Carter, B.S. & Macklis, J.D. J. Neurosci. 25, 10729–10739 (2005).

    CAS  Article  Google Scholar 

  15. 15

    Mouret, A. et al. J. Neurosci. 28, 11511–11516 (2008).

    CAS  Article  Google Scholar 

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We thank M. Alonso for technical help with viral injections and M. Grubb for insightful comments on the manuscript. A.N. was supported by the Pasteur Institute; and P.-M.L., by the Fondation pour la Recherche Médicale “Equipe FRM,” Agence Nationale de la Recherche (ANR-05-Neur-028-01), Ecole des Neurosciences de Paris and the Groupe Ionis. The Lledo laboratory is a member of the Network of European Neuroscience Institutes (LSHM-CT-2005-019063).

Author information




A.N. carried out the electrophysiology and immunochemistry, C.B. contributed to the electrophysiology and performed virus injections, H.K. contributed to analysis, and K.M. generated the lentiviral vectors. A.N. and P.-M.L. designed all of the experiments and wrote the manuscript.

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Correspondence to Pierre-Marie Lledo.

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Nissant, A., Bardy, C., Katagiri, H. et al. Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. Nat Neurosci 12, 728–730 (2009).

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