Abstract
Memories are dynamic, rather than static, in nature. The reactivation of a memory through re-exposure to salient training stimuli results in its destabilization, necessitating a restabilization process known as reconsolidation, a disruption of which leads to amnesia. I found that one normal function of hippocampal memory reconsolidation in rats is to modify the strength of a contextual-fear memory as a result of further learning.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Brief memory reactivations induce learning in the numeric domain
npj Science of Learning Open Access 17 August 2022
-
Sleep enhances reconsolidation-based strengthening of visuospatial memories
Scientific Reports Open Access 04 May 2022
-
Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation
Molecular Brain Open Access 07 May 2021
Access options
Subscribe to Journal
Get full journal access for 1 year
$79.00
only $6.58 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.
References
Nader, K. Trends Neurosci. 26, 65–72 (2003).
Dudai, Y. Curr. Opin. Neurobiol. 16, 174–178 (2006).
Sara, S.J. Learn. Mem. 7, 73–84 (2000).
Tronel, S., Milekic, M.H. & Alberini, C.M. PLoS Biol. 3, e293 (2005).
Morris, R.G. et al. Neuron 50, 479–489 (2006).
Rodriguez-Ortiz, C.J. et al. Neurobiol. Learn. Mem. 89, 352–359 (2008).
Lee, J.L.C., Everitt, B.J. & Thomas, K.L. Science 304, 839–843 (2004).
Lee, S.H. et al. Science 319, 1253–1256 (2008).
Duvarci, S. & Nader, K. J. Neurosci. 24, 9269–9275 (2004).
Rudy, J.W. et al. Learn. Mem. 13, 1–3 (2006).
Dudai, Y. Annu. Rev. Psychol. 55, 51–86 (2004).
Pelloux, Y., Everitt, B.J. & Dickinson, A. Psychopharmacology (Berl.) 194, 127–137 (2007).
Ben Mamou, C., Gamache, K. & Nader, K. Nat. Neurosci. 9, 1237–1239 (2006).
Suzuki, A. et al. Learn. Mem. 15, 426–433 (2008).
Acknowledgements
I'd like to thank B.J. Everitt and D. Belin for helpful discussions, as well as Y. Pelloux and M. Wood for practical cooperation. This work was supported by a grant from the Royal Society and was conducted in the MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology at the University of Cambridge (UK).
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–7 and Supplementary Methods (PDF 2561 kb)
Rights and permissions
About this article
Cite this article
Lee, J. Memory reconsolidation mediates the strengthening of memories by additional learning. Nat Neurosci 11, 1264–1266 (2008). https://doi.org/10.1038/nn.2205
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2205
This article is cited by
-
Brief memory reactivations induce learning in the numeric domain
npj Science of Learning (2022)
-
Optogenetic inhibition of the dorsal hippocampus CA3 region during early-stage cocaine-memory reconsolidation disrupts subsequent context-induced cocaine seeking in rats
Neuropsychopharmacology (2022)
-
Sleep enhances reconsolidation-based strengthening of visuospatial memories
Scientific Reports (2022)
-
Activation of acid‐sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation
Molecular Brain (2021)
-
d-Aspartate consumption selectively promotes intermediate-term spatial memory and the expression of hippocampal NMDA receptor subunits
Scientific Reports (2021)
