Abstract
We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.
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References
Qin, M., Kang, J., Burlin, T.V., Jiang, C. & Smith, C.B. J. Neurosci. 25, 5087–5095 (2005).
Bear, M.F., Huber, K.M. & Warren, S.T. Trends Neurosci. 27, 370–377 (2004).
Barbee, S.A. et al. Neuron 52, 997–1009 (2006).
Dubnau, J. et al. Curr. Biol. 13, 286–296 (2003).
Jin, P. et al. Nat. Neurosci. 7, 113–117 (2004).
Ashraf, S.I., McLoon, A.L., Sclarsic, S.M. & Kunes, S. Cell 124, 191–205 (2006).
Tully, T., Preat, T., Boynton, S.C. & Del Vecchio, M. Cell 79, 35–47 (1994).
Didelot, G. et al. Science 313, 851–853 (2006).
Michel, C.I., Kraft, R. & Restifo, L.L. J. Neurosci. 24, 5798–5809 (2004).
de Belle, J.S. & Heisenberg, M. Science 263, 692–695 (1994).
McBride, S.M. et al. Neuron 45, 753–764 (2005).
Chuang, S.C. et al. J. Neurosci. 25, 8048–8055 (2005).
Vanderklish, P.W. & Edelman, G.M. Proc. Natl. Acad. Sci. USA 99, 1639–1644 (2002).
Weiler, I.J. et al. Proc. Natl. Acad. Sci. USA 101, 17504–17509 (2004).
Muddashetty, R.S., Kelic, S., Gross, C., Xu, M. & Bassell, G.J. J. Neurosci. 27, 5338–5348 (2007).
Acknowledgements
F.V.B. conceptualized the project, conducted experiments and wrote the manuscript. K.B. carried out behavioral experiments, H.C. performed the imaging experiments and K.S.B. helped with conceptualization. T.T. conceptualized, supervised and funded the project and wrote the manuscript.
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Bolduc, F., Bell, K., Cox, H. et al. Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory. Nat Neurosci 11, 1143–1145 (2008). https://doi.org/10.1038/nn.2175
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DOI: https://doi.org/10.1038/nn.2175
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