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Neural repetition suppression reflects fulfilled perceptual expectations

Abstract

Stimulus-evoked neural activity is attenuated on stimulus repetition (repetition suppression), a phenomenon that is attributed to largely automatic processes in sensory neurons. By manipulating the likelihood of stimulus repetition, we found that repetition suppression in the human brain was reduced when stimulus repetitions were improbable (and thus, unexpected). Our data suggest that repetition suppression reflects a relative reduction in top-down perceptual 'prediction error' when processing an expected, compared with an unexpected, stimulus.

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Figure 1: Main experiment: protocol and results.
Figure 2: Control experiment protocol and results.

References

  1. 1

    Grill-Spector, K., Henson, R. & Martin, A. Trends Cogn. Sci. 10, 14–23 (2006).

    Article  Google Scholar 

  2. 2

    Henson, R.N. Prog. Neurobiol. 70, 53–81 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Miller, E.K., Li, L. & Desimone, R. Science 254, 1377–1379 (1991).

    CAS  Article  Google Scholar 

  4. 4

    Wiggs, C.L. & Martin, A. Curr. Opin. Neurobiol. 8, 227–233 (1998).

    CAS  Article  Google Scholar 

  5. 5

    Grill-Spector, K. & Malach, R. Acta Psychol. (Amst.) 107, 293–321 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Kourtzi, Z. & Kanwisher, N. Science 293, 1506–1509 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Desimone, R. Proc. Natl. Acad. Sci. USA 93, 13494–13499 (1996).

    CAS  Article  Google Scholar 

  8. 8

    Friston, K. Phil. Trans. R. Soc. Lond. B 360, 815–836 (2005).

    Article  Google Scholar 

  9. 9

    Henson, R., Shallice, T. & Dolan, R. Science 287, 1269–1272 (2000).

    CAS  Article  Google Scholar 

  10. 10

    Kanwisher, N., McDermott, J. & Chun, M.M. J. Neurosci. 17, 4302–4311 (1997).

    CAS  Article  Google Scholar 

  11. 11

    Murray, S.O. & Wojciulik, E. Nat. Neurosci. 7, 70–74 (2004).

    CAS  Article  Google Scholar 

  12. 12

    Friston, K., Kilner, J. & Harrison, L. J. Physiol. (Paris) 100, 70–87 (2006).

    Article  Google Scholar 

  13. 13

    Bar, M. & Aminoff, E. Neuron 38, 347–358 (2003).

    CAS  Article  Google Scholar 

  14. 14

    Kersten, D., Mamassian, P. & Yuille, A. Annu. Rev. Psychol. 55, 271–304 (2004).

    Article  Google Scholar 

  15. 15

    Summerfield, C. & Koechlin, E. Neuron published online, doi: 10.1016/j.neuron.2008.05.21 (2008).

Download references

Acknowledgements

We are grateful to E. Koechlin and S. Kouider for helpful comments on an earlier version of this manuscript. This work was supported in part by a grant from the US National Institute of Neurological Disorders and Stroke (NS30863, M.-M.M.).

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Authors

Contributions

C.S., T.E., E.H.T. and M.-M.M. conceived of the experiment, C.S. and T.E. designed the experiment, T.E., E.H.T. and J.M.M. collected the data, T.E. analyzed the data and C.S. and T.E. wrote the paper.

Corresponding author

Correspondence to Tobias Egner.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1 and 2, Supplementary Table 1 and Supplementary Methods (PDF 337 kb)

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Summerfield, C., Trittschuh, E., Monti, J. et al. Neural repetition suppression reflects fulfilled perceptual expectations. Nat Neurosci 11, 1004–1006 (2008). https://doi.org/10.1038/nn.2163

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