Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaΔENT/ΔENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaΔENT/ΔENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification.
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Fettiplace, R. & Hackney, C.M. Nat. Rev. Neurosci. 7, 19–29 (2006).
Dallos, P. in The Cochlea (eds. Dallos, P., Popper, A.N. & Fay, R.R.) 1–43 (Springer, New York, 1996).
Lukashkin, A.N., Walling, M.N. & Russell, I.J. Curr. Biol. 17, 1340–1345 (2007).
Robles, L. & Ruggero, M.A. Physiol. Rev. 81, 1305–1352 (2001).
Chan, D.K. & Hudspeth, A.J. Biophys. J. 89, 4382–4395 (2005).
Kennedy, H.J., Crawford, A.C. & Fettiplace, R. Nature 433, 880–883 (2005).
Legan, P.K. et al. Neuron 28, 273–285 (2000).
Nuttall, A.L. & Ren, T. Hear. Res. 92, 170–177 (1995).
Nowotny, M. & Gummer, A.W. Proc. Natl. Acad. Sci. USA 103, 2120–2125 (2006).
Karavitaki, K.D. & Mountain, D.C. Biophys. J. 92, 3294–3316 (2007).
Allen, J.B. & Fahey, P.F. J. Acoust. Soc. Am. 94, 809–817 (1993).
Murugasu, E. & Russell, I.J. Aud. Neurosci. 1, 139–150 (1995).
Oliver, D. et al. Science 292, 2340–2343 (2001).
Santos-Sacchi, J., Song, L., Zheng, J. & Nuttall, A.L. J. Neurosci. 26, 3992–3998 (2006).
Kennedy, H.J., Evans, M.G., Crawford, A.C. & Fettiplace, R. J. Neurosci. 26, 2757–2766 (2006).
We thank G. Richardson for making the Tecta mice available. We thank J. Hartley for technical assistance and C. Kros for helpful comments on the manuscript. This work was supported by the Medical Research Council. M.M.M.L. was supported by a Federation of European Neuroscientists—International Brain Research Organization Fellowship, and M.D. was supported by a Deutsche Forschungsgemeinschaft Fellowship.
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Mellado Lagarde, M., Drexl, M., Lukashkina, V. et al. Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Nat Neurosci 11, 746–748 (2008) doi:10.1038/nn.2129
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